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However, its clinical application is limited by tissue hypoxia, poor photosensitizer (PS) penetration, and off\u2010target toxicity. In this work, we use a light\u2010activated, contactless aPDT system that delivers airborne singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) via a compliant, transparent superhydrophobic (SH) bandage. The verteporfin\u2010coated SH membrane generates\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    while minimizing direct contact between PS and wound tissue. In a murine third\u2010degree burn model infected with methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) or\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    , a single SH\u2010aPDT treatment significantly reduces bacterial burden and accelerates wound closure. It enhances collagen deposition, stimulates angiogenesis, increases \u03b1\u2010SMA\n                    <jats:sup>+<\/jats:sup>\n                    myofibroblast activity, and decreases COX\u20102 expression, indicating attenuated inflammatory signaling. Administration of two treatments 24\u00a0h apart further augments bacterial clearance and improves healing outcomes. SH\u2010aPDT also promotes a pro\u2010regenerative immune response, as evidenced by increased M2 macrophages. These findings demonstrate that airborne\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    delivery through SH bandages is a promising approach for the management of infected, hypoxic, or antibiotic\u2010resistant wounds, with great potential for clinical translation in wound care.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71083","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:47:15Z","timestamp":1774604835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Airborne\n                    <sup>1<\/sup>\n                    O\n                    <sub>2<\/sub>\n                    Delivery via a Superhydrophobic Dressing as a Pathway to Next\u2010Generation Wound Therapies, an In Vivo Murine Burn Model Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6247-2220","authenticated-orcid":false,"given":"Fernanda Viana","family":"Cabral","sequence":"first","affiliation":[{"name":"Wellman Center for Photomedicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9067-3644","authenticated-orcid":false,"given":"QianFeng","family":"Xu","sequence":"additional","affiliation":[{"name":"SingletO2 Therapeutics LLC  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Eidenschink","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pareesha","family":"Haresh","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6768-2670","authenticated-orcid":false,"given":"Alessandra Nara de Souza","family":"Rastelli","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry School of Dentistry Sao Paulo State University \u2013 UNESP  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Goverman","sequence":"additional","affiliation":[{"name":"Sumner M. Redstone Burn Center Department of Surgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4444-9099","authenticated-orcid":false,"given":"Alexander","family":"Greer","sequence":"additional","affiliation":[{"name":"SingletO2 Therapeutics LLC  Newark New Jersey USA"},{"name":"Ph.D. Program in Chemistry The Graduate Center of the City University of New York  New York New York USA"},{"name":"Department of Chemistry Brooklyn College City University of New York  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4410-9756","authenticated-orcid":false,"given":"Alan M.","family":"Lyons","sequence":"additional","affiliation":[{"name":"SingletO2 Therapeutics LLC  Newark New Jersey USA"},{"name":"Ph.D. Program in Chemistry The Graduate Center of the City University of New York  New York New York USA"},{"name":"Department of Chemistry College of Staten Island City University of New York  Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0871-6057","authenticated-orcid":false,"given":"Tayyaba","family":"Hasan","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Health Sciences and Technology Harvard University and Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u20100145\u20105"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.2.403\u2010434.2006"},{"key":"e_1_2_11_4_1","unstructured":"World Health Organization Burns accessed 10 July 2025 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/burns."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010015\u20100961\u20102"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07039"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/8854311"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/1040841X.2018.1467876"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-55858-0_5-1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13774"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13470"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116881"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13461"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2021.112236"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2022.112563"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2010.04.004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.12.889"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.5978\/islsm.27_18\u2010RA\u201001"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u20101097.2010.00792.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.117197"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.02.041"},{"key":"e_1_2_11_22_1","first-page":"251","article-title":"Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy","volume":"7","author":"Hamblin M. 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