{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:42:24Z","timestamp":1792186944162,"version":"4.4.0"},"reference-count":59,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005145","name":"Basic Research Program of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20250382"],"award-info":[{"award-number":["BK20250382"]}],"id":[{"id":"10.13039\/501100005145","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Nanoplastics (NPs) are emerging environmental pollutants with widespread human exposure and potential health risks. Once entering biological systems, NPs readily acquire a protein corona (PC) that governs their biological identity and toxicity. However, how disease\u2010associated microenvironments reshape PC and modulate NPs toxicity remains poorly understood. Here, we investigated the effects of the oral inflammatory microenvironment on PC and the biological behavior of polystyrene (PS) NPs using periodontitis as a model disease. We identified a disease\u2010specific PC formed in the saliva of periodontitis patients, characterized by enrichment of apolipoproteins, complement, and coagulation proteins. Compared with the normal PC, this disease\u2010specific PC markedly enhanced macrophage uptake of PS NPs via increased phagocytosis and lipid raft\/caveolin\u2010mediated endocytosis, and triggered stronger pro\u2010inflammatory responses, including elevated reactive oxygen species production, M1 macrophage polarization, and cytokine secretion. In vivo, oral exposure to PS NPs exacerbated alveolar bone loss and inflammation in a periodontitis mouse, accompanied by enhanced macrophage M1 polarization and systemic inflammatory responses. Mechanistically, these effects were closely associated with the complement\u2010enriched disease\u2010specific PC that amplified NPs\u2010immune cell interactions. Overall, this study demonstrates that inflammatory microenvironments can reshape the PC of NPs and intensify their toxicological outcomes, underscoring the need for health\u2010dependent risk assessment of NPs.<\/jats:p>","DOI":"10.1002\/adhm.71098","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:46:18Z","timestamp":1775029578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inflammatory Microenvironment Reshapes the Protein Corona of Polystyrene Nanoplastics to Exacerbate Periodontitis Progression"],"prefix":"10.1002","volume":"15","author":[{"given":"Can","family":"Chen","sequence":"first","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital, Gusu School Nanjing Medical University  Suzhou China"},{"name":"Department of Genetic Toxicology Center For Global Health School of Public Health The Key Laboratory of Modern Toxicology of Ministry of Education Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yang","sequence":"additional","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital, Gusu School Nanjing Medical University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital, Gusu School Nanjing Medical University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8964-208X","authenticated-orcid":false,"given":"Shijun","family":"Lu","sequence":"additional","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital, Gusu School Nanjing Medical University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minxuan","family":"Han","sequence":"additional","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital, Gusu School Nanjing Medical University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"He","sequence":"additional","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital, Gusu School Nanjing Medical University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixi","family":"Yang","sequence":"additional","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital, Gusu School Nanjing Medical University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shao","sequence":"additional","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital, Gusu School Nanjing Medical University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital, Gusu School Nanjing Medical University  Suzhou China"},{"name":"Department of Genetic Toxicology Center For Global Health School of Public Health The Key Laboratory of Modern Toxicology of Ministry of Education Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Song","sequence":"additional","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital, Gusu School Nanjing Medical University  Suzhou China"},{"name":"Department of Genetic Toxicology Center For Global Health School of Public Health The Key Laboratory of Modern Toxicology of Ministry of Education Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4996-958X","authenticated-orcid":false,"given":"Meilin","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital, Gusu School Nanjing Medical University  Suzhou China"},{"name":"Department of Genetic Toxicology Center For Global Health School of Public Health The Key Laboratory of Modern Toxicology of Ministry of Education Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010025\u201002409\u20104"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41893\u2010025\u201001554\u20104"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010025\u201000"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010021\u201000888\u20102"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010025\u201000971\u20100"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010025\u201003902\u20105"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2023.117206"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5c04146"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c13214"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.138908"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.137596"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12989\u2010024\u201000563\u2010z"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.157948"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.136168"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.135034"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c04097"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.175433"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.136809"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c05772"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.2c00650"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c00014"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c05087"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR02788J"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.02.012"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010023\u201001455\u20107"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056210\u20104"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2025.109759"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13357"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.133339"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202508761"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00636A"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001452\u20101"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.01.064"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201067289\u2010y"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.125423"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08851"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.763334"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202506121"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123713"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13217"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13357"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8EN00087E"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202412612"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.04.020"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805740"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c10790"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20031000"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010eular.1894"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.08.048"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010018\u20100344\u20103"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2020.0094"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010025\u201002728\u2010x"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001273\u20104"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.05.015"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2021.08.001"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2018.01.001"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010025\u201000361\u2010z"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.124004"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c11734"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:19:28Z","timestamp":1792185568000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":59,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/adhm.71098"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71098","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"2026-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71098"}}