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Activating the cyclic GMP\u2010AMP synthase\u2010stimulator of interferon genes (cGAS\u2010STING) pathway to stimulate innate immunity is considered a promising strategy for TNBC treatment. However, current STING agonists are limited by several severe drawbacks that hinder their further application. Herein, a cross\u2010shaped DNA skeleton was rationally engineered by leveraging programmable DNA assembly and AS1411 aptamer\u2010mediated tumor targeting to achieve specific activation of the cGAS\u2010STING pathway. The DNA nanoarchitecture exhibited outstanding resistance to nuclease\u2010mediated degradation and achieved nucleolin\u2010targeted cellular internalization, thereby facilitating efficient activation of the cGAS\u2010STING signaling cascade and eliciting potent innate immune responses. In vitro and in vivo evaluations further validated that the DNA scaffold not only triggered innate immune activation but also inhibited tumor progression in TNBC models. Overall, this work provides a promising strategy for the development of safe and effective TNBC immunotherapy.<\/jats:p>","DOI":"10.1002\/adhm.71114","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T09:07:53Z","timestamp":1774861673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assembled DNA Nanostructure to Precisely Induced cGAS\u2010STING Activation for Cancer Immunotherapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Li","family":"He","sequence":"first","affiliation":[{"name":"School of Life Sciences and Health Engineering Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wuxi School of Medicine Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Health Engineering Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixu","family":"Kou","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Health Engineering Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Health Engineering Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Health Engineering Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4485-8872","authenticated-orcid":false,"given":"Zhaoqi","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Health Engineering Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6092-9522","authenticated-orcid":false,"given":"Teng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology Affiliated Hospital of Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201004460\u2010w"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2023.2210845"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14171875"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400046"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010023\u201001850\u20107"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201039920\u20105"},{"key":"e_1_2_8_8_1","article-title":"Bidirectional Regulation of the cGAS\u2010STING Pathway in the Immunosuppressive Tumor Microenvironment and Its Association with Immunotherapy","volume":"15","author":"Zhang Y. 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