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Here, it is developed a pathological microenvironment\u2013responsive catalytic carbon nanodot delivery platform (PPOD@CeCDs) featuring dual reversible covalent cross\u2010linking mediated by phenylboronate ester and Schiff base bonds, which selectively senses the acidic and highly oxidative milieu characteristic of IVDD to enable on\u2010demand release of cerium\u2010doped carbon nanodots (CeCDs), thereby intercepting the ROS\u2010driven inflammatory cascade at its oxidative origin. PPOD@CeCDs exhibits favorable injectability, controllable degradability, biocompatibility, and robust antioxidant activity, together with stable intradiscal retention and stimulus\u2010responsive release under pathological conditions. In vitro, PPOD@CeCDs protects nucleus pulposus (NP) cells from oxidative injury, suppresses inflammation amplification by modulating the ROS\u2010driven PI3K\u2013Akt\u2013NF\u2010\u03baB signaling axis, regulates macrophage polarization, and preserves extracellular matrix homeostasis. In a rat model of IVDD, intradiscal injection of PPOD@CeCDs mitigates matrix degradation and promotes structural restoration of degenerative discs. Collectively, by integrating a microenvironment\u2010responsive hydrogel with catalytically active carbon nanodots, this strategy sustainably intercepts ROS\u2010driven inflammatory cascades and offers a mechanistically defined, translationally promising therapeutic approach for IVDD.<\/jats:p>","DOI":"10.1002\/adhm.71151","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T07:43:57Z","timestamp":1776152637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Pathological Microenvironment\u2013Responsive Catalytic Carbon Nanodots Release Platform Intercepting the ROS\u2013Inflammation Cascade to Alleviate Intervertebral Disc Degeneration"],"prefix":"10.1002","volume":"15","author":[{"given":"Xiang","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Orthopedics The Second Affiliated Hospital Jiangxi Medical College Nanchang University  Nanchang Jiangxi 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