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Although microwave ablation (MWA) is a viable treatment option for non\u2010surgical patients, its effectiveness is often compromised by substantial complications and inadequate prevention of tumor recurrence or progression. To address these limitations, we developed a multifunctional hydrogel system (aPD1@Cur\u2010Mg\/GH) that integrates antitumor immunomodulation with pleural sealing capabilities. This hydrogel combines a gelatin methacryloyl (GelMA)\/o\u2010nitrobenzyl alcohol\u2010modified hyaluronate (HANB) matrix (GH) with an aPD1\u2010loaded curcumin\u2010embedded magnesium\u2010polyphenol network (Cur\u2010Mg\/aPD1). By utilizing the photocrosslinking properties of GelMA and HANB, the aPD1@Cur\u2010Mg\/GH hydrogel forms a robust, adhesive, and compression\u2010resistant structure that is ideal for pleural sealing and tissue repair. Upon degradation, the hydrogel releases Mg\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    ions and curcumin, which promote M1 macrophage polarization and enhance CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration, thereby synergizing with MWA to improve the efficacy of immune checkpoint blockade therapy. Our findings demonstrate that this dual\u2010functional hydrogel significantly modulates the post\u2010ablation tumor immune microenvironment and presents a promising strategy for enhancing lung cancer immunotherapy following MWA.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71157","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:03:31Z","timestamp":1777712611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Curcumin\u2010Embedded Magnesium\u2010Polyphenol Network Hydrogel for Dual Delivery of aPD1 and Promotion of Pleural Sealing in Lung Cancer Immunotherapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Xuhui","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Key Laboratory of Tissue Engineering Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 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