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Meanwhile, free radical damage and severe inflammation caused by bacterial invasion remain key clinical challenges. To address these issues, we developed a novel metal\u2010phenolic nanoparticles (FCTP), which were self\u2010assembled from ferric ions (Fe\n                    <jats:sup>3<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    ), curcumin, tannic acid, and \u03b5\u2010poly\u2010L\u2010lysine through metal\u2010phenolic networks and electrostatic interactions, and were loaded onto a dissolvable microneedle (MN) system for the treatment of bacterial keratitis. In vitro assays demonstrated that the obtained FCTP nanoparticles exhibited a potent and rapid bactericidal activity by disrupting the bacterial biofilm. They can also scavenge excessive free radicals in the corneal cells. Moreover, FCTP nanoparticles regulated macrophage polarization from M1 to M2 by modulating phosphorylation of NF\u2010\u03baB pathway kinases, significantly inhibiting pro\u2010inflammatory cytokines (IL\u20106, TNF\u2010\u03b1) and upregulating anti\u2010inflammatory IL\u201010. In Vivo experiments verified that FCTP\u2010loaded dissolvable MNs penetrated the corneal barrier and biofilm. Compared with eye drops, the MN showed superior efficacy in eradicating bacteria, relieving ocular inflammation, and promoting corneal epithelialization with a single administration. Overall, this multifunctional nanoplatform provides a promising strategy for ocular diseases by targeting infection, oxidative stress, inflammation, and physiological barriers.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71181","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T11:18:33Z","timestamp":1776683913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Triple\u2010Modal \u201cOne\u2010Stone\u2010for\u2010Three\u2010Birds\u201d Strategy: Breaking Ocular Barriers to Combat Bacterial Keratitis With Antibacterial, Antioxidant and Anti\u2010Inflammatory"],"prefix":"10.1002","volume":"15","author":[{"given":"Dan","family":"Ying","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering South China University of Technology  Guangzhou P. R. 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