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Herein, we propose a molecular mechanism that elucidates the wound healing by in vivo ascorbic acid (AA) levels, using a carbon\u2010based \u201cmonitor\u2010and\u2010treat\u201d platform. The platform demonstrates significant antibacterial efficacy against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    , high\u2010performance AA detection in real\u2010world samples, and AA monitoring in murine blood. Based on the monitoring, a dynamic correlation model between in vivo AA levels and wound healing stages is established. Leveraging the model, an AA\u2010based molecular mechanism for wound healing is further established, which is thoroughly investigated from both biomedical and materials science perspectives. Based on these surveys, this work not only confirms that AA depletion serves as a critical indicator of wound healing, but more importantly, reveals that the dynamic depletion of AA itself directly accelerates antibacterial activity, as it initiates early\u2010stage, ROS\u2010mediated bacterial killing and consequent Mn\n                    <jats:sup>2+<\/jats:sup>\n                    \/Mn\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010driven antibacterial model. Our study contributes novel insights into AA\u2010related molecular mechanisms that govern wound healing.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71195","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:24:02Z","timestamp":1777274642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wound Healing Correlates With Ascorbic Acid Depletion: A Carbon\u2010Based \u201cMonitor\u2010and\u2010Treat\u201d Platform for In Vivo Dynamics Tracking and Antibacterial Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Ziqian","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Qilu University of Technology (Shandong Academy of Sciences)  Jinan P. R. 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