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Here, we report an NIR\u2010II emissive AIE small molecule that can be rapidly assembled into monodisperse nanoparticles (NDA\u2010MEPA NPs, \u223c40\u00a0nm) using a microfluidic strategy that ensures reproducible control over particle size and uniformity. Surface encapsulation with DSPE\u2010PEG2K confers excellent colloidal stability, biocompatibility, and enhanced tumor accumulation. The resulting NDA\u2010MEPA NPs exhibit efficient photothermal conversion under 808\u00a0nm irradiation, along with dose\u2010 and time\u2010dependent cellular uptake, and induce robust photothermal cytotoxicity in vitro. In vivo evaluations demonstrated that NDA\u2010MEPA NPs enable high\u2010contrast NIR\u2010II fluorescence imaging and effective photothermal tumor ablation with minimal systemic toxicity. This work establishes a programmable microfluidic approach for constructing NIR\u2010II AIE nanomaterials and highlights a biocompatible photothermal platform with strong potential for translational cancer therapy.<\/jats:p>","DOI":"10.1002\/adhm.71201","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:13:09Z","timestamp":1777713189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microfluidic Assembly of NIR\u2010II AIE Nanoparticles for Enhanced Photothermal Ablation of Breast Tumors"],"prefix":"10.1002","volume":"15","author":[{"given":"Xiaohua","family":"Ji","sequence":"first","affiliation":[{"name":"Qingdao Medical College Qingdao University Qingdao Shandong P. R. 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