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Metal\u2010organic framework (MOF)\u2010based nanozymes integrate MOF's high surface area with nanozyme catalytic properties but face toxicity issues from degradation byproducts. Herein, this study engineered a bio\u2010MOF nanozyme using vitamin B3 as the ligand, featuring stability (the degradation rate was less than 50% in PBS for 28 days), biocompatibility (the bio\u2010MOF nanozyme concentration threshold for cell compatibility was as high as 150\u00a0\u00b5g\/mL), and pH\u2010responsive dual enzymatic activities. In the acidic bacterial microenvironment (pH = 6.5), it activates superoxide dismutase (SOD) and peroxidase (POD) mimetic activities, generating \u00b7OH for bactericidal effects. The antibacterial efficacy against\n                    <jats:italic>E.coli<\/jats:italic>\n                    and\n                    <jats:italic>S.aureus<\/jats:italic>\n                    was both higher than 99%. Under neutral conditions (pH = 7.4), it switches to SOD and catalase (CAT) mimetic modes, scavenging ROS and releasing O\n                    <jats:sub>2<\/jats:sub>\n                    to create a reparative microenvironment. In vivo rat infected wound models confirmed enhanced antibacterial efficacy, inhibited excessive fibroblast proliferation, reduced aberrant collagen deposition and scar area, promoting scarless healing. The proposed dual\u2010pathway coordinated regulation of antibacterial\u2010antioxidant mechanisms provides a novel material strategy for addressing cutaneous fibrosis.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71208","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:23:02Z","timestamp":1778059382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intelligent Bio\u2010MOF Nanozymes With Dual Antibacterial and Antioxidant Capabilities Through pH\u2010Modulated Double Cascade Reactions for Anti\u2010Fibrosis"],"prefix":"10.1002","volume":"15","author":[{"given":"Jinquan","family":"Huang","sequence":"first","affiliation":[{"name":"Key Laboratory of Advanced Technology for Materials of Chinese Education Ministry, School of Materials Sciences and Engineering Southwest Jiaotong University  Chengdu 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