{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:21:29Z","timestamp":1789708889674,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Long\u2010term excessive alcohol consumption and unhealthy lifestyles disrupt gastric homeostasis, increasing the risk of gastritis and gastric ulcers. However, conventional synthetic drugs are often limited by poor bioavailability, low antioxidant capacity, and gastrointestinal toxicity. In this study, a sodium alginate\u2010based composite hydrogel loaded with\n                    <jats:italic>Lactobacillus rhamnosus<\/jats:italic>\n                    JM023 postbiotics was successfully developed. The hydrogel exhibited favorable mechanical properties (G' &gt; G''), slow degradation (retaining more than 95% mass after simulated gastrointestinal digestion), and excellent biocompatibility (maximum hemolysis rate of 3.10%). It significantly alleviated gastric bleeding and reduced ulcer area (ulcer proportion: 9.67 \u00b1 3.54%). Mechanistically, the hydrogel exerted antioxidant and anti\u2010inflammatory effects by enhancing SOD, GSH, and CAT activities, downregulating TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106, and modulating the Nrf2\/HO\u20101 and NF\u2010\u03baB signaling pathways. It also restored gut microbiota homeostasis by increasing the relative abundance of beneficial genera, including\n                    <jats:italic>Allobaculum<\/jats:italic>\n                    ,\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    ,\n                    <jats:italic>Adlercreutzia<\/jats:italic>\n                    , and\n                    <jats:italic>Oscillospira<\/jats:italic>\n                    . Overall, this study presents a novel and effective strategy for alleviating alcohol\u2010induced gastric ulcers using\n                    <jats:italic>Lactobacillus rhamnosus<\/jats:italic>\n                    JM023 postbiotic\u2010loaded composite hydrogels.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71236","type":"journal-article","created":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T08:44:27Z","timestamp":1778402667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Lactobacillus rhamnosus<\/i>\n                    JM023 Postbiotic\u2010Loaded Sodium Alginate Hydrogel for Alleviating Alcoholic Gastric Ulcers"],"prefix":"10.1002","volume":"15","author":[{"given":"Yuanyuan","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Dairy Science Ministry of Education College of Food Science Northeast Agricultural University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifu","family":"Jia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Dairy Science Ministry of Education College of Food Science Northeast Agricultural University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiewei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Dairy Science Ministry of Education College of Food Science Northeast Agricultural University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Huo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Dairy Science Ministry of Education College of Food Science Northeast Agricultural University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Dairy Science Ministry of Education College of Food Science Northeast Agricultural University Harbin China"},{"name":"Heilongjiang Probiotic Industry Technology Innovation Alliance Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2857-2137","authenticated-orcid":false,"given":"Yujun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Dairy Science Ministry of Education College of Food Science Northeast Agricultural University Harbin China"},{"name":"Heilongjiang Probiotic Industry Technology Innovation Alliance Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Dairy Science Ministry of Education College of Food Science Northeast Agricultural University Harbin China"},{"name":"Heilongjiang Probiotic Industry Technology Innovation Alliance Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Dairy Science Ministry of Education College of Food Science Northeast Agricultural University Harbin China"},{"name":"Heilongjiang Probiotic Industry Technology Innovation Alliance Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)00155\u20107"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010022\u201002130\u20102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015486"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.113661"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.05.040"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.01.008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12060"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2021.05.004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010021\u201000440\u20106"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2018.03.009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4FO03591G"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.142549"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12934\u2010020\u201001426\u2010w"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.2c01062"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO02947E"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123283"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.05.021"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010022\u201001236\u20100"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.11.093"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128871"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201008355\u20102"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197\u2010025\u201006403\u2010y"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128005"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128015"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.05.163"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.126388"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2023.105033"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201081183\u2010x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875\u20105364(24)60559\u20105"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1223621"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2023.113492"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010022\u201020543\u20100"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3069089"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123845"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119822"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2022.100172"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735\u2010022\u201010072\u2010y"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2023.102145"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1003627"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114260"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.116057"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00040.2012"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.04.069"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00099\u201020"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202105738"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154954"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13726"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.622815"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418\u2010018\u20101256\u20100"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010024\u201003026\u20106"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010020\u201003198\u20107"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1223621"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.S280429"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.12.034"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S372389"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1324396"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118921"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2023.103187"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71236","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:28:26Z","timestamp":1782509306000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,10]]},"references-count":58,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/adhm.71236"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71236","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,10]]},"assertion":[{"value":"2026-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71236"}}