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The high level of glutathione (GSH) in the tumor microenvironment (TME) and hypoxic characteristics significantly restrict the production of reactive oxygen species (ROS). Furthermore, the existing excitation light is unable to penetrate deep tissues, which extremely limits the effect of PDT on deep tumors. Herein, we develop a nanoplatform (UDNPs@MOF:DATS@cRGD\u2010PEG, abbreviated as UMDP), which combines with upconversion\/down\u2010shifting nanoparticles (UDNPs), MOF composed of Fe\n                    <jats:sup>3+<\/jats:sup>\n                    and meso\u2010tetra(4\u2010carboxyphenyl)porphine (TCPP), diallyl trisulfide (DATS), as well as active targeting peptide (cRGD\u2010PEG). UDNPs can tune the excitation source to 1530\u00a0nm, which increases the penetration depth in vivo. MOF containing Fe\n                    <jats:sup>3+<\/jats:sup>\n                    coated on UDNPs and DATS loaded in the MOF channel can regulate the levels of dissolved oxygen and GSH in the TME, improving ROS generation. H\n                    <jats:sub>2<\/jats:sub>\n                    S generated by the reaction of DATS with GSH can produce a gas therapy (GT) effect. The active targeting effect of cRGD\u2010PEG increases UMDP accumulation at the tumor site. The key advantage of UMDP lies in breakthrough tissue penetration depth and the mutually reinforcing therapy mechanisms, which overcome the bottleneck of traditional PDT and provide a novel strategy for enhancing the PDT\/GT synergistic effect of deep\u2010seated tumors.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71253","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:48:41Z","timestamp":1778647721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrin\u2010Targeted Delivery of Redox Homeostasis Regulating Lanthanide\u2010Based Composite Nanoplatform for Deep Self\u2010Enhanced Photodynamic\/H\n                    <sub>2<\/sub>\n                    S Gas Synergistic Therapy via 1530\u00a0nm Activation"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7856-7352","authenticated-orcid":false,"given":"Jitong","family":"Gong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China Hefei Anhui 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Chinese Academy of Sciences Changchun Jilin China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukai","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2850-0990","authenticated-orcid":false,"given":"Jing","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin China"},{"name":"School of Applied Chemistry and Engineering University 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