{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:49:12Z","timestamp":1782510552840,"version":"3.54.5"},"reference-count":61,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102017\u201006455"],"award-info":[{"award-number":["RGPIN\u20102017\u201006455"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    While polydimethylsiloxane (PDMS) has been widely applied in biomedical devices and implants, its interfacial hydrophobicity and poor blood compatibility limit its long\u2010term effectiveness. Existing approaches to enhance the surface hydrophilicity and reduce the interfacial biological responses of PDMS implants often result in a gradual loss of hydrophilicity due to the chemical instability of the coating and\/or the hydrophobic recovery of the low surface energy silicone. Herein, dynamic covalent crosslinking of a Schiff base\u2010crosslinked silicone elastomer (PDMS\n                    <jats:sub>S<\/jats:sub>\n                    ) with an anti\u2010fouling hydrazide\u2010functionalized poly(oligoethylene glycol methacrylate) (OEGMA\u2010Hzd) or zwitterionic sulfobetaine (DMAPS\u2010Hzd) polymer is demonstrated to improve the long\u2010term hydrophilicity and anti\u2010fouling properties of PDMS. Dip coating PDMS\n                    <jats:sub>S<\/jats:sub>\n                    into a hydrazide\u2010functionalized polymer solution significantly improved both the interfacial and bulk properties of the material, increasing its tensile and compressive strength while preventing hydrophobic recovery over at least 100 days, significantly longer than most reported approaches. Blood\u2010contacting studies show the material resists clotting, while subcutaneous implants indicate a significant reduction in immune cell density at the tissue\u2010implant interface as well as a decrease in capsule thickness and collagen deposition compared to PDMS\n                    <jats:sub>S<\/jats:sub>\n                    and Sylgard PDMS. This dynamic covalent crosslinking approach can thus address a key barrier to the fabrication of tissue\u2010compatible and long\u2010term hydrophilic PDMS\u2010based biomedical implants.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71278","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T08:44:20Z","timestamp":1779957860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Hydrophilic, Anti\u2010Clotting, and Anti\u2010Fibrotic Dynamic Covalent Silicone\u2010Based Biomaterials"],"prefix":"10.1002","volume":"15","author":[{"given":"Norma A.","family":"Garza Flores","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bui","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Fredenburgh","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Thrombosis and Atherosclerosis Research Institute McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6890-9964","authenticated-orcid":false,"given":"Ruiqi","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Thrombosis and Atherosclerosis Research Institute McMaster University  Hamilton Ontario 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