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The singlet oxygen battery (SOB) offers a promising approach to circumvent these limitations by realizing oxygen\u2010 and light\u2010independent singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) release triggered by H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    during therapy phase. However, its inherent uncontrolled release characteristics reduce therapeutic precision and safety. Herein, a conjugate\n                    <jats:bold>BTMI\u2010PyB<\/jats:bold>\n                    was constructed to store\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    via dynamic boronic ester bonds. Upon light irradiation,\n                    <jats:bold>BTMIs\u2010PyB<\/jats:bold>\n                    underwent a \u201c\n                    <jats:italic>self\u2010charging<\/jats:italic>\n                    \u201d process utilizing the\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    generated by\n                    <jats:bold>BTMIs<\/jats:bold>\n                    to yield\n                    <jats:bold>BTMIs\u2010PyOB<\/jats:bold>\n                    . Notably, the resulting intelligent nanosystem could achieve targeted delivery to colon cancer cells by leveraging the specific recognition between mannose and the CD206 receptor. Experiments on 2D cells, 3D cell spheres and tumor bearing mice demonstrated that\n                    <jats:bold>BTMIs\u2010PyOB<\/jats:bold>\n                    could induce CT26 cell death through highly efficient type I\/II PDT upon light irradiation. Moreover, under dark and hypoxic conditions,\n                    <jats:bold>BTMIs\u2010PyOB<\/jats:bold>\n                    could be activated by overexpressed H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    in the tumor microenvironment to release\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . This advancement breaks through the dependence of traditional PDT on light and oxygen, providing a novel therapeutic strategy for the treatment of deep\u2010seated tumors by integrating conventional PDT with stimulus\u2010responsive therapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71280","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T05:02:08Z","timestamp":1779858128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A CD206\u2010Targeted Singlet\u2010Oxygen Battery for Type I\/II Photodynamic Therapy of Deep\u2010Seated Colorectal Cancer"],"prefix":"10.1002","volume":"15","author":[{"given":"Wei","family":"Zhou","sequence":"first","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing China"},{"name":"College of Chemistry and Chemical Engineering Liaoning Normal University  Dalian 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Translational Research (Ministry of Education\/Beijing) Gastrointestinal Cancer Center Peking University Cancer Hospital and Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-7569","authenticated-orcid":false,"given":"Guo\u2010wen","family":"Xing","sequence":"additional","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing 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