{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:58:56Z","timestamp":1785376736983,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62201031"],"award-info":[{"award-number":["62201031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["FRF\u2010IDRY\u2010GD24\u2010002"],"award-info":[{"award-number":["FRF\u2010IDRY\u2010GD24\u2010002"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic wounds such as diabetic foot ulcers and burns pose clinical challenges due to persistent inflammation and impaired endogenous bioelectric signaling. Here, we report a self\u2010powered piezoelectric nanofibrous hydrogel for synergistic electro\u2010pharmacological therapy, fabricated via dual\u2010nozzle electrospinning and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    crosslinking. This therapeutic paradigm facilitates a dual\u2010action mechanism that integrates direct biophysical stimulation with electro\u2010kinetically accelerated drug delivery, both driven autonomously by physiological motion. This platform integrates a \u03b2\u2010phase\u2010rich poly(vinylidene fluoride\n                    <jats:italic>\u2010co\u2010<\/jats:italic>\n                    trifluoroethylene) (PVDF\u2010TrFE) matrix with an ion\u2010crosslinked polyvinyl alcohol\u2010sodium alginate (PVA\u2010SA) hydrogel, successfully transforming a hydrophobic interface into a hydrophilic one and matching human skin's modulus (1.8\u20132.1 MPa). By encapsulating immunomodulator resveratrol (RSV) and bactericidal silver nanoparticles (Ag NPs), the dressing converts biomechanical energy into therapeutic bioelectric potentials (0.3\u20133.0 V). Mechanistically, the motion\u2010induced piezoelectric field generates electro\u2010kinetic driving forces that actively upregulate the transport rate constant (\n                    <jats:italic>K<\/jats:italic>\n                    ) by reducing the energy barrier for molecular diffusion, thereby accelerating RSV bioavailability beyond passive diffusion. In a\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    \u2013infected chronic wound model, the synergy significantly facilitates wound closure (95.8%\n                    <jats:italic>vs<\/jats:italic>\n                    63.3% by day 10) by effectively suppressing inflammation, promoting angiogenesis, and accelerating collagen maturation, with excellent biocompatibility and no systemic toxicity. This study establishes a scalable strategy for recalcitrant inflammatory injuries and motion\u2010associated pathologies.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71297","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:11:26Z","timestamp":1780031486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self\u2010Powered Piezoelectric Nanofibrous Hydrogel for Synergistic Electro\u2010Pharmacological Therapy of Chronic Wounds"],"prefix":"10.1002","volume":"15","author":[{"given":"Baoyu","family":"Wang","sequence":"first","affiliation":[{"name":"School of Mathematics and Physics University of Science and Technology Beijing  Beijing China"},{"name":"Department of Biomedical Engineering and Technology Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Mathematics and Physics University of Science and Technology Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Li","sequence":"additional","affiliation":[{"name":"School of Mathematics and Physics University of Science and Technology Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chubin","family":"Wan","sequence":"additional","affiliation":[{"name":"School of Mathematics and Physics University of Science and Technology Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ju","sequence":"additional","affiliation":[{"name":"School of Mathematics and Physics University of Science and Technology Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Technology Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-0738","authenticated-orcid":false,"given":"Ruodan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Technology Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Technology Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2025.02.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaf118"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c12513"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.147145"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c11986"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.02.034"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.01.024"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c14487"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b07038"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c12448"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c15743"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2024.102120"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202315086"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c13074"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2017.11.023"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialslett.5c00641"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.03.047"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c13026"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2011.06.003"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14070789"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2013.07.006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.07.010"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700527"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25020747"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401105"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c05381"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c01864"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2020.105599"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.105156"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2019.04.048"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2006.12.045"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10118\u2010025\u20103302\u20101"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2018.12.077"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13213790"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020449"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2004"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04925"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmm2.12020"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201909045"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202005941"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2017.12.046"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/193293a0"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.700"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2023.2210834"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378\u20105173(83)90064\u20109"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010024\u201007266\u20103"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010017\u20100308\u2010z"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b03162"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201603497"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71297","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71297","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:26:28Z","timestamp":1785374788000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":49,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/adhm.71297"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71297","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]},"assertion":[{"value":"2026-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71297"}}