{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:58:56Z","timestamp":1785376736997,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Although injectable hydrogels hold promise as dressings for chronic diabetic wounds, their clinical potential is often limited by non\u2010specific actions and modest efficacy. To address these limitations, we developed a novel injectable hydrogel by integrating\n                    <jats:italic>Bletilla striata<\/jats:italic>\n                    polysaccharide (BSP)\u2014known for its biocompatibility and wound\u2010healing properties\u2014with\n                    <jats:italic>alpha<\/jats:italic>\n                    \u2010lipoic acid (LA), a potent antioxidant and antimicrobial agent. The preparation process is straightforward, requiring only the mixing of LA dissolved in Tris buffer (LA\u2010Tris) and BSP solutions, and the gelation time was inversely correlated with BSP content. The resulting BSP\/LA hydrogel displayed excellent injectability, appropriate mechanical strength, reliable tissue adhesion, and tunable degradation and swelling behaviors. By leveraging the synergistic effects of BSP and LA, the hydrogel exhibited strong broad\u2010spectrum antimicrobial and antioxidant activities. Both in vitro and in vivo evaluations confirmed its high biocompatibility. Notably, in a diabetic rat wound model, the BSP\/LA hydrogel significantly accelerated wound closure, attenuated inflammatory responses, stimulated collagen deposition, and enhanced neovascularization compared to control groups. These collective findings underscore the potential of this multifunctional injectable hydrogel as an effective and clinically viable dressing for the management of complex chronic wounds.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71299","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:34:36Z","timestamp":1781156076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Injectable and Self\u2010Adhesive Hydrogel Dressing Synergizing Natural Polysaccharide and Antioxidant for Promoting Healing of Chronic Wounds"],"prefix":"10.1002","volume":"15","author":[{"given":"Cuiyun","family":"Yin","sequence":"first","affiliation":[{"name":"Yunnan Branch Institute of Medicinal Plant Development Yunnan Key Laboratory of Southern Medicine Utilization Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Jinghong 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