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Herein, a multifunctional hydrogel KAE@ZIF\u20108\/Mg\n                    <jats:sup>2+<\/jats:sup>\n                    \/PDA\u2010NIPAM\u2010PAM (abbreviated as KAE@ZIF\u20108\/Mg\n                    <jats:sup>2+<\/jats:sup>\n                    \/PNP) was prepared by copolymerizing dopamine, N\u2010isopropylacrylamide, and acrylamide with kaempferol\u2010loaded ZIF\u20108 nanoparticles. The hydrogel integrates thermosensitive gelation and bioadhesion delivery to treat diabetic wounds. It forms gel within 1\u00a0min at 37\u00b0C with reliable tissue adhesion, while adhesion drops sharply after 20\u00a0min immersion at 10\u00b0C for trauma\u2010free detachment. This hydrogel achieves pH\u2010responsive drug release, with 24\u00a0h cumulative KAE release rates of 49.8\u00a0\u00b1\u00a01.33% at pH 5.3 and 18.1\u00a0\u00b1\u00a00.82% at pH 7.4. It possesses excellent hemostatic, pro\u2010angiogenic, anti\u2010inflammatory, and antioxidant properties. Moreover, the hydrogel exhibits a compressive modulus of 89.98\u00a0kPa and favorable cytocompatibility, maintaining over 90% viability of NIH\/3T3 fibroblasts.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71304","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:55:29Z","timestamp":1779944129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kaempferol\u2010ZIF\u20108 Hybrid System Augments Bioadhesive Thermoresponsive Hydrogel for Enhanced Diabetic Wound Healing"],"prefix":"10.1002","volume":"15","author":[{"given":"Xinyue","family":"Wei","sequence":"first","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei Anhui 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