{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:58:54Z","timestamp":1785376734108,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62035011"],"award-info":[{"award-number":["62035011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202220"],"award-info":[{"award-number":["82202220"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260613"],"award-info":[{"award-number":["82260613"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060326"],"award-info":[{"award-number":["82060326"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62275166"],"award-info":[{"award-number":["62275166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cervical cancer (CC) treatment is limited by chemoresistance, inadequate drug accumulation, and the lack of real\u2010time monitoring. Among the underlying mechanisms, heat shock protein 70 (HSP70) mediates resistance to both chemotherapy and photothermal therapy, making it a rational target for intervention. To address these issues, we developed a novel type of cyclic RGD (cRGD) encapsulated SN38 and IR820 loaded bismuth selenide theranostic nanoplatforms\u2010Bi\n                    <jats:sub>2<\/jats:sub>\n                    Se\n                    <jats:sub>3<\/jats:sub>\n                    \u2010cRGD@SN38\/IR820 nanoparticles (Bi\u2010A@SR NPs) based on a bismuth selenide (Bi\n                    <jats:sub>2<\/jats:sub>\n                    Se\n                    <jats:sub>3<\/jats:sub>\n                    ) as core decorated with cRGD for tumor targeting, and co\u2010loaded with SN38 and IR820. The RGD peptide contains a guanidino group from its arginine residue that can serve as a donor for nitric oxide (NO) generation, enabling the construct to provide both tumor\u2010homing capability and on\u2010demand NO release. The nanoplatform integrates computed tomography (CT) imaging and NIR fluorescence imaging (NIRF) to verify delivery and guide therapy. Upon 808\u00a0nm irradiation, photothermal and photodynamic effects generate hyperthermia and reactive oxygen species (ROS), which trigger on\u2010site NO production from the RGD arginine moiety. This NO suppresses therapy\u2010induced HSP70 upregulation, counteracting stress adaptation and enhancing chemo\u2013phototherapy efficacy. By combining imaging\u2010guided delivery, on\u2010demand NO sensitization, and HSP70 inhibition, this nanotheranostic strategy offers a coordinated approach to improving treatment outcomes in CC.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71321","type":"journal-article","created":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T04:41:08Z","timestamp":1780807268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bi\u2010A@SR Nanoparticles Enable Tumor\u2010Localized NO Release to Suppress HSP70 and Reverse Chemoresistance"],"prefix":"10.1002","volume":"15","author":[{"given":"Meihaguli","family":"Abulaizi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence, Diseases in Central Asia, Department of Gynecology The First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maierhaba","family":"Aili","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence, Diseases in Central Asia, Department of Gynecology The First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Du","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Xinjiang Medical University, The Second School of Clinical Medicine Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabao","family":"Xiong","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Xinjiang Medical University, The Second School of Clinical Medicine Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5807-8439","authenticated-orcid":false,"given":"Cailing","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence, Diseases in Central Asia, Department of Gynecology The First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence, Diseases in Central Asia, Department of Gynecology The First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuernisha","family":"Alifu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Xinjiang Medical University, The Second School of Clinical Medicine Xinjiang Medical University  Urumqi China"},{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, School of Medical Engineering and Technology Xinjiang Medical University  Urumqi China"},{"name":"Science and Technology Innovation and Outcome Transformation Service Center Xinjiang Medical University  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5274-1703","authenticated-orcid":false,"given":"Biao","family":"Dong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, School of Medical Engineering and Technology Xinjiang Medical University  Urumqi China"},{"name":"State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12629"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010021\u201004249\u20104"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010023\u201001997\u20109"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.04.033"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.05.026"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21642"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.34133\/2021\/9816594"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c02964"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2021.10.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13040601"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16081500"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16030638"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.942828"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11082276"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201021\u20102087"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400819"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010022\u201000454\u20105"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010022\u201001313\u20104"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13111917"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002929\u2010z"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30132802"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102468"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5cc00219b"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303259"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2023.07.017"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c02303"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010021\u201001078\u2010x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230163"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.3c00250"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.01.009"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29245985"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238\u2010023\u201001262\u20103"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2021.01.014"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6800"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.79625"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1801"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28155921"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01998"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b05427"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201601050"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.855019"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010023\u201002111\u2010x"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.842682"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16040490"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.795012"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c00306"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36685"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.11.037"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c00891"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.09.004"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/polymscitech.5c00068"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.984166"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202100117"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5c02318"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b01771"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.11.107"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c01537"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.02.005"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206707"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202522094"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71321","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:25:53Z","timestamp":1785374753000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,6]]},"references-count":61,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/adhm.71321"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71321","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,6]]},"assertion":[{"value":"2026-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71321"}}