{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:55:10Z","timestamp":1787756110233,"version":"build-2784847793"},"reference-count":280,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Biomaterials are substances designed to interact with living systems for diagnostic, therapeutic, or regenerative purposes. Their clinical success is governed not only by their bulk physicochemical properties but more importantly, by their surface properties and interfacial characteristics, which regulate early protein adsorption and subsequently downstream cellular responses. Biocompatibility, therefore, extends far beyond the absence of toxicity, encompassing the ability of a material to modulate the foreign body response, promote tissue repair, and tissue integration. Understanding these mechanisms is essential for designing materials that minimize fibrous encapsulation while enhancing regeneration. This need becomes particularly evident in dental implantology, where biomaterials are indispensable for functional rehabilitation, yet biological complications continue to represent a major clinical challenge. In response to these limitations, recent advances in surface engineering and nanotechnology have facilitated the development of bioactive materials to enhance healing outcomes. Building upon these developments, the present review compiles and critically examines current evidence on interactions between a biomaterial surface and surrounding tissue, with a particular emphasis on host response, regulatory frameworks, and their translational implications. Furthermore, it discusses preclinical validation strategies in accordance with ISO guidelines and proposes a pragmatic roadmap for clinical translation, with special attention to the importance of regulatory alignment.<\/jats:p>","DOI":"10.1002\/adhm.71335","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T09:17:08Z","timestamp":1781947028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8651-1312","authenticated-orcid":false,"given":"Daniela Moreira","family":"Cunha","sequence":"first","affiliation":[{"name":"Department of Dental Materials and Prosthodontics School of Dentistry at Ara\u00e7atuba S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3356-414X","authenticated-orcid":false,"given":"Amanda Paino","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Surgery School of Dentistry S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Maria Alves","family":"Pereira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Piaui (UFPI)  Teresina Piaui Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Martins","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics School of Dentistry at Ara\u00e7atuba S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Mauro","family":"Granjeiro","sequence":"additional","affiliation":[{"name":"Department of Dental Clinic School of Dentistry Fluminense Federal University (UFF)  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil Awad","family":"Shibli","sequence":"additional","affiliation":[{"name":"Department of Periodontology Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"},{"name":"Faculdade Israelita de Ci\u00eancias da Sa\u00fade Albert Einstein Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"},{"name":"Department of Oral Medicine Infection and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"},{"name":"Department of Oral Health Sciences Periodontology KU Leuven &amp; Dentistry University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-1966","authenticated-orcid":false,"given":"Jeroen J. J. P.","family":"van den Beucken","sequence":"additional","affiliation":[{"name":"Dentistry \u2010 Regenerative Biomaterials Radboudumc  Nijmegen Gelderland the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-5477","authenticated-orcid":false,"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1110-6233","authenticated-orcid":false,"given":"Rafael Scaf","family":"de Molon","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Surgery School of Dentistry S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6681-1269","authenticated-orcid":false,"given":"Erica Dorigatti","family":"de Avila","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Surgery School of Dentistry S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.07.027"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2196\/58080"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm\u20102019\u20100140"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10750"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202002153"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010015\u20105423\u20105"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbw041"},{"issue":"3","key":"e_1_2_10_9_1","first-page":"10","article-title":"pH\u2010Sensitive Chitosan Hydrogel with Instant Gelation for Myocardial Regeneration","volume":"8","author":"Alimirzaei F.","year":"2017","journal-title":"Journal of Tissue Science and Engineering"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.matsci.31.1.81"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.004"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.04.023"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEB.2020.0276"},{"key":"e_1_2_10_14_1","unstructured":"Businesswire Global Dental Biomaterials Market: Increasing Prevalence of Dental Condition to Propel Revenue Growth (2026) https:\/\/www.businesswire.com\/news\/home\/20201104005389\/en\/Global\u2010Dental\u2010Biomaterials\u2010Market\u2010Increasing\u2010Prevalence\u2010of\u2010Dental\u2010Condition\u2010to\u2010Propel\u2010Revenue\u2010Growth."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302702"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201405310"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101635"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6246576"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2010.0151.focus"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JMSM.0000042685.63383.86"},{"key":"e_1_2_10_21_1","volume-title":"Biomaterials Science","author":"Ratner B. D.","year":"2004"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741\u20105214(94)70083\u20104"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20104636(19980915)41:4<511::aid\u2010jbm1>3.0.co;2\u2010f"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493529"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.12.019"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1151\u20102916.1991.tb07132.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym15051313"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma8095269"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40883\u2010025\u201000443\u20108"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.11.012"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11837\u2010008\u20100031\u20101"},{"key":"e_1_2_10_32_1","unstructured":"RSC Publishing Advances in Implant Surface Modifications to Improve Osseointegration September 23 2025 https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2021\/ma\/d1ma00675d."},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.02.005"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493018778713"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10578"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c00114"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.03.055"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.v45.i1\u20106.160"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2017.02.002"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34218"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2017.08.004"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2018.05.006"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2015.00194"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067404"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b00889"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.03.014"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2958"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2441"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2019.0094"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.11.015"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1515\/bglass\u20102017\u20100009"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010006\u20100434\u2010x"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202300224"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856204323005352"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.08.023"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10853-017-0946-4"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1055"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.010"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3920"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171643"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00252"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.07.031"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.022"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12580"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2021.07.014"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12938\u2010015\u20100037\u20101"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010024\u201001707\u20106"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.69.5.1767"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.6563"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.11.011"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115653"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coisb.2019.10.011"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1020"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101747.2000.00029.x"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.565"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102249.2004.02709.x"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2021_540"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00185"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2016.07.003"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1191774"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109796"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1292"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802123380706"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.3.1848"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3362"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.1"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI14122"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/33169"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960\u20109822(98)70438\u20105"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1828"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00004"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2012.0407"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121087"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201300087"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030636"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v98.4.1231"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142\u20109612(92)90100\u20103"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1988.tb02815.x"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113367"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2006.06.020"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00491"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.15.8841"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam9690"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173090"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116389"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.07.052"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.10.019"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3bm00629h"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEB.2021.0010"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2005.09.002"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2448"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22916"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.08.029"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.03.038"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax3799"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad9272"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aar8356"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801419"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9bm01802f"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.201900572"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.4.1863"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.617141"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.05.053"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20104636(20011205)57:3<336::aid\u2010jbm1176>3.0.co;2\u2010e"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010004\u20105668\u2010x"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33676"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.10.046"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30075"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf6654"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.10.065"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100045\u20101804889"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.12.003"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34666"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13522"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401253"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.05.014"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.06.010"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010014\u20101796\u20108"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060989"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.02.065"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010013\u20100933\u20100"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.09.063"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20104636(199802)39:2<190::aid\u2010jbm4>3.0.co;2\u2010k"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2005.12.007"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.04.066"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200106"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2010.0148"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018\u2010023\u201003865\u20108"},{"key":"e_1_2_10_150_1","volume-title":"Biomaterials Science","author":"Sanati M.","year":"2025"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010018\u20100040\u20104"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22625"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00255"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800675"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100783"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010bioeng\u2010062117\u2010121224"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518767120"},{"key":"e_1_2_10_158_1","unstructured":"ISO 10993\u20101:2018(en) Biological Evaluation of Medical Devices \u2014 Part 1: Evaluation and Testing Within a Risk Management Process February 09 2024. Available:https:\/\/www.iso.org\/obp\/ui\/en\/#iso:std:iso:10993:\u20101:ed\u20105:v2:en."},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.05.078"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1269960"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16035517"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1089\/adt.2014.573"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2011.09.005"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.08.005"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn404501g"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/0267\u20106605(92)90085\u20108"},{"key":"e_1_2_10_167_1","volume-title":"Biocompatibility Evaluation Endpoints by Device Category","author":"FDA","year":"2023"},{"key":"e_1_2_10_168_1","unstructured":"FDA Basics of Biocompatibility: Information Needed for Assessment by the FDA September. 23 2025 https:\/\/www.fda.gov\/medical\u2010devices\/biocompatibility\u2010assessment\u2010resource\u2010center\/basics\u2010biocompatibility\u2010information\u2010needed\u2010assessment\u2010fda."},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/0267\u20106605(92)90085\u20108"},{"key":"e_1_2_10_170_1","volume-title":"Biological Evaluation of Medical Devices Part 4: Selection of Tests for Interactions With Blood","author":"International Organization for Standardization","year":"2017"},{"key":"e_1_2_10_171_1","volume-title":"Biological Evaluation of Medical Devices \u2014 Part 11: Tests for Systemic Toxicity","author":"International Organization for Standardization","year":"2017"},{"key":"e_1_2_10_172_1","volume-title":"Biological Evaluation of Medical Devices Part 12: Sample Preparation and Reference","author":"International Organization for Standardization","year":"2021"},{"key":"e_1_2_10_173_1","volume-title":"FDA Guidance on Biocompatibility Evaluation ISO 10993\u20101 Insights on Biocompatibility Evaluation","author":"Kohli V.","year":"2025"},{"key":"e_1_2_10_174_1","volume-title":"Medical Device Guidelines and Regulations Handbook","author":"Thangaraju P.","year":"2022"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.1c01119"},{"key":"e_1_2_10_176_1","volume-title":"ISO 10993\u201018:2020(en), Biological Evaluation of Medical Devices \u2014 Part 18: Chemical Characterization of Medical Device Materials Within a Risk Management Process","author":"International Organization for Standardization","year":"2020"},{"key":"e_1_2_10_177_1","unstructured":"International Organization for Standardization. April 15 2026 https:\/\/www.iso.org\/standard\/82241.html."},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2021.06.012"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v16.i10.860"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414\u2010431X20165644"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2024.1474583"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2024.116496"},{"key":"e_1_2_10_183_1","volume-title":"Biocompatibility and Performance of Medical Devices","author":"Boutrand J.\u2010P.","year":"2019"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2024.105612"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.5599\/admet.1513"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00036.2016"},{"key":"e_1_2_10_187_1","volume-title":"Biological Evaluation of Medical Devices Part 18: Chemical Characterization of Medical Device Materials Within a Risk Management Process","author":"International Organization for Standardization","year":"2020"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168657"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.09.038"},{"key":"e_1_2_10_190_1","volume-title":"Biological Evaluation of Medical Devices \u2014 Part 2: Animal Welfare Requirements","author":"International Organization for Standardization","year":"2022"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1177\/026119291003800208"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2025.01.002"},{"key":"e_1_2_10_193_1","volume-title":"Biological Evaluation of Medical Devices Part 6: Tests for Local Effects After Implantation","author":"International Organization for Standardization","year":"2016"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.22\u20100091"},{"key":"e_1_2_10_195_1","volume-title":"Biological Evaluation of Medical Devices Part 10: Tests for Irritation and Skin Sensitization","author":"International Organization for Standardization","year":"2010"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010025\u201005964\u2010w"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0323666"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123491"},{"key":"e_1_2_10_199_1","volume-title":"Biologia Molecula","author":"Girardi C. S.","year":"2026"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00444"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202501941"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201015743\u2010w"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2007.01518.x"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c00160"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.01.022"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12938\u2010020\u20100752\u20100"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios14050225"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.24171"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301472"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202502773"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10020102"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-388-2_18"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2024.105278"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1755565"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10924\u2010024\u201003376\u20105"},{"key":"e_1_2_10_216_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1755565"},{"key":"e_1_2_10_217_1","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2019\u2010140"},{"key":"e_1_2_10_218_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13121"},{"key":"e_1_2_10_219_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12502"},{"key":"e_1_2_10_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.004"},{"key":"e_1_2_10_221_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453678608994393"},{"key":"e_1_2_10_222_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453679809000938"},{"key":"e_1_2_10_223_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2017.0048"},{"key":"e_1_2_10_224_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.3232"},{"key":"e_1_2_10_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.03.001"},{"key":"e_1_2_10_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.09.072"},{"issue":"5","key":"e_1_2_10_227_1","first-page":"536","article-title":"Oral Implant Surfaces: Part 1\u2013Review Focusing on Topographic and Chemical Properties of Different Surfaces and In Vivo Responses to Them","volume":"17","author":"Albrektsson T.","year":"2004","journal-title":"International Journal of Prosthodontics"},{"key":"e_1_2_10_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.02.026"},{"key":"e_1_2_10_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.02.071"},{"key":"e_1_2_10_230_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.1"},{"key":"e_1_2_10_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.11.004"},{"key":"e_1_2_10_232_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.4891"},{"key":"e_1_2_10_233_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12975"},{"key":"e_1_2_10_234_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12054"},{"key":"e_1_2_10_235_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856206777346340"},{"key":"e_1_2_10_236_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2008.0038"},{"key":"e_1_2_10_237_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12274"},{"key":"e_1_2_10_238_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12532"},{"key":"e_1_2_10_239_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1466417"},{"key":"e_1_2_10_240_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779\u2010024\u201000532\u20109"},{"key":"e_1_2_10_241_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7279509"},{"key":"e_1_2_10_242_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12410"},{"key":"e_1_2_10_243_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12285"},{"key":"e_1_2_10_244_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12039"},{"key":"e_1_2_10_245_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26103007"},{"key":"e_1_2_10_246_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729\u2010022\u201000421\u20107"},{"key":"e_1_2_10_247_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748\u2010605X\/ad967c"},{"key":"e_1_2_10_248_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma16114117"},{"key":"e_1_2_10_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2021.01.043"},{"key":"e_1_2_10_250_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2013.08.018"},{"key":"e_1_2_10_251_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb13040187"},{"key":"e_1_2_10_252_1","doi-asserted-by":"publisher","DOI":"10.1080\/26415275.2021.1925556"},{"key":"e_1_2_10_253_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906\u20106713.2003.03304.x"},{"key":"e_1_2_10_254_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.qi.a37133"},{"key":"e_1_2_10_255_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13770\u2010025\u201000704\u20101"},{"key":"e_1_2_10_256_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12157"},{"key":"e_1_2_10_257_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.2.215"},{"key":"e_1_2_10_258_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100757.2011.00438.x"},{"key":"e_1_2_10_259_1","doi-asserted-by":"publisher","DOI":"10.3390\/membranes12050444"},{"key":"e_1_2_10_260_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2009.01740.x"},{"key":"e_1_2_10_261_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2019.03.011"},{"issue":"2","key":"e_1_2_10_262_1","first-page":"1146","article-title":"Cross\u2010Linking Methods of Type I Collagen\u2010Based Scaffolds for Cartilage Tissue Engineering","volume":"14","author":"Jiang Y.\u2010H.","year":"2022","journal-title":"American journal of translational research"},{"key":"e_1_2_10_263_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2004.01100.x"},{"issue":"2","key":"e_1_2_10_264_1","first-page":"123","article-title":"Use of a Collagen Barrier to Enhance Healing in Human Periodontal Furcation Defects","volume":"12","author":"Paul B. F.","year":"1992","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_10_265_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.10145"},{"key":"e_1_2_10_266_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering12080876"},{"key":"e_1_2_10_267_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2005.01108.x"},{"key":"e_1_2_10_268_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12470"},{"key":"e_1_2_10_269_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2015.09.002"},{"key":"e_1_2_10_270_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b11453"},{"key":"e_1_2_10_271_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c01037"},{"key":"e_1_2_10_272_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.117604"},{"key":"e_1_2_10_273_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.04.011"},{"key":"e_1_2_10_274_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101555"},{"key":"e_1_2_10_275_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2019.05.154"},{"key":"e_1_2_10_276_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c19344"},{"key":"e_1_2_10_277_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.5c00120"},{"key":"e_1_2_10_278_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.10.038"},{"key":"e_1_2_10_279_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.12.004"},{"key":"e_1_2_10_280_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008208\u2010z"},{"key":"e_1_2_10_281_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252312766"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71335","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71335","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:52:21Z","timestamp":1784296341000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,20]]},"references-count":280,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/adhm.71335"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71335","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,20]]},"assertion":[{"value":"2026-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71335"}}