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Poreless structures like curing sealants are effective in preventing CSF leakage in dural defects but are often biologically inert. Here, we report a dura\u2010inspired collagen hydrogel (DICH) consisting of dense\u2013porous heterogeneous bilayers fabricated via a dual\u2010channel freeze casting (abbreviated as Freezing\u2010While\u2010Lifting, FWL), which enables biocompatibility without compromising CSF sealing. The dense layer (DL) is formed through directional collagen molecular self\u2010assembly followed by cross\u2010linking, while the porous layer (PL) originates from collagen Pickering emulsion\u2010templated self\u2010assembly without cross\u2010linking. By tuning collagen concentration and cross\u2010linking density, the DL achieves optimized mechanical strength, whereas increasing the emulsification shear rate enhances pore interconnectivity and porosity in the PL. Compared with dense patches, DICH effectively prevents CSF leakage while promoting tissue compatibility and a minimal inflammatory response. At day 28, implantation studies in a rat model show histocompatibility comparable to that of the commercial DuraGen membrane, suggesting its potential as a dural substitute. This work establishes a facile biomimetic strategy for constructing dense\u2013porous hydrogels with potential applications in tissue engineering.<\/jats:p>","DOI":"10.1002\/adhm.71337","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:05:26Z","timestamp":1782972326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Asymmetric Dura\u2010Inspired Collagen Hydrogel Patch with Integrated Dense\u2013Porous Architecture Enabled by Dual\u2010Channel Freeze Casting"],"prefix":"10.1002","volume":"15","author":[{"given":"Kaiwen","family":"Liang","sequence":"first","affiliation":[{"name":"College of Material Engineering Fujian Agriculture and Forestry University Fuzhou P. R. 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