{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:08:05Z","timestamp":1784297285188,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102022"],"award-info":[{"award-number":["82102022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20752"],"award-info":[{"award-number":["U24A20752"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400308"],"award-info":[{"award-number":["82400308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L242038"],"award-info":[{"award-number":["L242038"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Doxorubicin\u2010induced cardiomyopathy (DIC) remains a major dose\u2010limiting complication of anthracycline chemotherapy, with no effective targeted therapies available. Emerging evidence suggests that maladaptive inflammation, driven by aberrant monocyte recruitment, synergizes with oxidative stress to exacerbate myocardial injury. In particular, the CCL2\u2010CCR2 chemokine axis plays a pivotal role in inflammatory cell trafficking and disease progression. An engineered biomimetic nanozyme, termed CCR2\u2010MM@Mn\/CeZ, is developed for inflammation\u2010targeted cardioprotection. This platform comprises a Mn\/Ce co\u2010doped ZIF\u20108 nanozyme core with intrinsic antioxidant activity, cloaked by macrophage membranes (MM) overexpressing CCR2. This design enables selective homing to inflamed myocardium via CCL2 recognition, prolonged cardiac retention, and simultaneous modulation of inflammatory and oxidative microenvironments. In a DIC mouse model, CCR2\u2010MM@Mn\/CeZ significantly enhances myocardial accumulation, suppresses pro\u2010inflammatory macrophage infiltration, promotes M2 polarization, and reduces intracellular reactive oxygen species. Transcriptomic analysis further reveals coordinated downregulation of inflammatory pathways and restoration of redox and metabolic homeostasis. Meanwhile, Mn\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010mediated T1\u2010weighted magnetic resonance imaging enables noninvasive visualization of myocardial targeting. Collectively, this chemokine\u2010axis\u2010guided biomimetic nanozyme integrates targeted delivery, immunomodulation, oxidative stress suppression, and diagnostic imaging, offering a promising strategy for DIC theranostics.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71347","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:26:09Z","timestamp":1781238369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemokine\u2010Guided Biomimetic Mn\/Ce Nanozymes for Immunomodulation and Cardioprotection in Doxorubicin\u2010Induced Cardiomyopathy"],"prefix":"10.1002","volume":"15","author":[{"given":"Zhi\u2010Nan","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Radiology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Radiology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidong","family":"Hu","sequence":"additional","affiliation":[{"name":"Senior Department of General Surgery the First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Geng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials College of Materials Science and Engineering Donghua University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Radiology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Radiology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Time Medical Ltd. Hong Kong Science &amp; Technology Park  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-1910","authenticated-orcid":false,"given":"Ying\u2010Shi","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Radiology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120463"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2023.101205"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-021-00487-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8016"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010020\u20100348\u20101"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-022-09721-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01077-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104846"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012\u2010020\u201009581\u20107"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103066"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103079"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01565-0"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109088"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S269029"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.975367"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1497026"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314649"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10030661"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.121.316091"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00520-5"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY15M12_03"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00437B"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622320974833"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37150-3"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01251-w"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwz037"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01746-6"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1BM01664D"},{"issue":"45","key":"e_1_2_10_30_1","article-title":"Genetically Engineered Cell Membrane\u2010Coated Nanoparticles with High\u2010Density Customized Membrane Receptor for High\u2010Performance Drug Lead Discovery","volume":"15","author":"Bu Y.","year":"2023","journal-title":"ACS Applied Materials & Interfaces"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302131"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c23163"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/gch2.202300244"},{"issue":"34","key":"e_1_2_10_34_1","first-page":"7023","article-title":"Zeolitic Imidazolate Frameworks (ZIF\u20108) for Biomedical Applications: A Review","volume":"28","author":"Abdelhamid H. N.","year":"2021","journal-title":"Current medicinal chemistry"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c05722"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026923"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21714-2"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119500"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206854"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202307569"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S253125"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2419"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-022-03262-w"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201708007"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010051"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10101575"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314030"},{"key":"e_1_2_10_48_1","doi-asserted-by":"crossref","unstructured":"S. F.Dent R.Kikuchi andL.Kondapalli \u201cPractical Review of Risk Assessment Monitoring and Prevention of Cancer Treatment\u2010related Cardiovascular Toxicity \u201d inAnnual Meeting(American Society of Clinical Oncology 2020) 1.","DOI":"10.1200\/EDBK_286019"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.65258"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.2c01863"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47841"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202305659"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71347","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71347","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:51:39Z","timestamp":1784296299000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":51,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/adhm.71347"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71347","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]},"assertion":[{"value":"2026-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71347"}}