{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:44:37Z","timestamp":1790102677750,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22171112"],"award-info":[{"award-number":["22171112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo Municipality","doi-asserted-by":"publisher","award":["2023J261"],"award-info":[{"award-number":["2023J261"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["lzujbky\u20102023\u2010stlt01"],"award-info":[{"award-number":["lzujbky\u20102023\u2010stlt01"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pyroptosis has emerged as a promising antitumor strategy offering unique advantages in overcoming apoptosis resistance and activating antitumor immunity. However, the development of drugs capable of achieving spatiotemporally controlled pyroptosis remains a challenge. Herein, we engineered a folate\u2010targeted liposomal nanoplatform to deliver a Ru(II) complex photosensitizer (\n                    <jats:bold>Ru\u2010Thi@Lipo\u2010FA<\/jats:bold>\n                    ) for pyroptosis\u2010mediated photodynamic therapy. The Ru(II) complex (\n                    <jats:bold>Ru\u2010Thi<\/jats:bold>\n                    ), acting as a photosensitizer, can produce singlet oxygen and superoxide anions and facilitate the photocatalytic oxidation of NADH through multiple mechanisms to kill tumor cells under white light irradiation. Additionally, we encapsulated the complex within folic acid\u2010modified liposomes, which markedly boosted cellular uptake efficiency and tumor targeting, leading to improved therapeutic effects. Mechanistic investigations demonstrated that light\u2010triggered reactive oxygen species generation activates the caspase\u20103\/GSDME\u2010mediated pyroptosis pathway. This study demonstrated a rationally designed, targeted nanoplatform that utilizes a multifunctional Ru(II)\u2010based photosensitizer and induces pyroptosis, providing a viable approach to improve the efficacy of tumor photodynamic therapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71351","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:28:22Z","timestamp":1781324902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Folate\u2010Targeted Liposomal Delivery of a Ru(II)\u2010Based Photosensitizer for Photodynamic Tumor Therapy via Pyroptosis Induction"],"prefix":"10.1002","volume":"15","author":[{"given":"Can","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Pharmacy Ningbo No.6 Hospital  Ningbo P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang","family":"Xu","sequence":"additional","affiliation":[{"name":"Cixi Biomedical Research Institute Key Laboratory of Laboratory Medicine School of Laboratory Medicine and Life sciences Ministry of Education Wenzhou Medical University  Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Peng","sequence":"additional","affiliation":[{"name":"Cixi Biomedical Research Institute Key Laboratory of Laboratory Medicine School of Laboratory Medicine and Life sciences Ministry of Education Wenzhou Medical University  Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manchang","family":"Kou","sequence":"additional","affiliation":[{"name":"MOE Frontiers Science Center for Rare Isotopes Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province College of Chemistry and Chemical Engineering Lanzhou University  Lanzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hand Microsurgery and Plastic Reconstructive Surgery Ningbo No.6 Hospital  Ningbo P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Tang","sequence":"additional","affiliation":[{"name":"MOE Frontiers Science Center for Rare Isotopes Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province College of Chemistry and Chemical Engineering Lanzhou University  Lanzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifa","family":"Shen","sequence":"additional","affiliation":[{"name":"Cixi Biomedical Research Institute Key Laboratory of Laboratory Medicine School of Laboratory Medicine and Life sciences Ministry of Education Wenzhou Medical University  Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"Ru","sequence":"additional","affiliation":[{"name":"Cixi Biomedical Research Institute Key Laboratory of Laboratory Medicine School of Laboratory Medicine and Life sciences Ministry of Education Wenzhou Medical University  Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22393"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010020\u201000630\u20103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102079\u20101"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3599"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00883"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202508713"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202513815"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c12264"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01579"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c00192"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/procel\/pwae049"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202410336"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010019\u20100228\u20102"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.71086"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010020\u201000985\u20100"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010024\u201000196\u2010z"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00173B"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010020\u20100926\u20103"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c03256"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202210988"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202016399"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c01929"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202400728"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202103978"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2020.213714"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010021\u201000265\u20106"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010019\u20100328\u20104"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202015671"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202100469"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202103346"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2020.213640"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029572\u20102"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202319966"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11426\u2010022\u20101440\u20102"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7cs00195a"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1cs00468a"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/B917757D"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201905171"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2025.2470309"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4dt01345j"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5QI00996K"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01106"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202501884"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.5c02119"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00624"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201030721\u2010w"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025174\u20106"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201700548"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c02488"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001850"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b19840"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.3c01015"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3tb00720k"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB03315C"},{"key":"e_1_2_10_57_1","volume-title":"Gaussian 16 Rev. C.01","author":"Frisch M. J.","year":"2016"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.22885"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2020.05.023"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:52:33Z","timestamp":1784296353000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":58,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/adhm.71351"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71351","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,12]]},"assertion":[{"value":"2025-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71351"}}