{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:03:24Z","timestamp":1785240204159,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"28","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472019"],"award-info":[{"award-number":["82472019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Molecular imaging is deeply involved in the\n 90<\/jats:sup>\n Y selective internal radiotherapy (\n 90<\/jats:sup>\n Y\u2010SIRT), exemplified as the pre\u2010operation simulation imaging by\n 99m<\/jats:sup>\n Tc\u2010MAA and postoperation imaging by\n 90<\/jats:sup>\n Y bremsstrahlung SPECT or PET. However, the former was limited by the nature differences between MAA and therapeutic microspheres, and the latter was hampered by the inherent limitations of bremsstrahlung SPECT or the low positron yield of\n 90<\/jats:sup>\n Y. We developed a new\n 90<\/jats:sup>\n Y\u2010microsphere and its imaging protocol. Streptavidin\u2010decorated polystyrene microspheres (SPS) were synthesized as the embolic agent. A complementary imaging pair,\n 68<\/jats:sup>\n Ga\u2010labeled biotin ([\n 68<\/jats:sup>\n Ga]Ga\u2010Biotin), was designed for in situ labeling. After intra\u2010arterial embolization of\n nat<\/jats:sup>\n Y\u2010SPS, [\n 68<\/jats:sup>\n Ga]Ga\u2010Biotin was administrated via vein to specifically bind to pre\u2010localized microspheres, thus achieving in situ labeling and self\u2010reporting of the distribution by PET imaging. The SPS exhibited excellent\n 90<\/jats:sup>\n Y capture capacity in vitro, and\n 90<\/jats:sup>\n Y\u2010SPS demonstrated stability in PBS and serum. When [\n 68<\/jats:sup>\n Ga]Ga\u2010Biotin was administrated separately, clear liver background was observed to provide high contrast. When [\n 68<\/jats:sup>\n Ga]Ga\u2010biotin was administrated to rat pre\u2010embolized with\n nat<\/jats:sup>\n Y\u2010SPS, it could rapidly recognize and bind to\n nat<\/jats:sup>\n Y\u2010SPS to report their in vivo distribution. Hepatic\u2010pulmonary shunt and hepatic\u2010abdominal shunt of SPS were calculated. When loaded peritumorally,\n 90<\/jats:sup>\n Y\u2010SPS showed strong antitumor effects while remained low biological toxicity. Tumor inhibition rate was nearly 90%. This bioorthogonal in situ labeling platform overcame the critical imaging limitations of conventional\n 90<\/jats:sup>\n Y\u2010SIRT. It provided a robust method to self\u2010report the spatial distribution of therapeutic microspheres via PET imaging, while maintained the strong antitumor effects.\n <\/jats:p>","DOI":"10.1002\/adhm.71355","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:53:48Z","timestamp":1781762028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["90<\/sup>\n Y Radioactive Microsphere and its In Situ Labeling Strategy in Biological Systems for Real\u2010Time Distribution Visualization after Embolization"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1968-1976","authenticated-orcid":false,"given":"Xinmiao","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Chongqing Medical University Chongqing 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