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However, the hypoxic microenvironment typically arises during type\u2010I PDT can upregulate apoptosis\u2010suppressing genes and promote immunosuppression, thereby facilitating tumor cell survival, invasion, and metastasis. To address these limitations, we integrated the charge\u2010transport material PFN\u2010Br with an NFA (H1) to construct bulk heterostructured nanoparticles (H2 (10:1)@NPs). This structural design not only promoted J\u2010aggregation of H2\u2010NPs, but also enhanced their spin\u2010orbit coupling (SOC) through the external heavy\u2010atom effect, thereby facilitating efficient intersystem crossing (ISC) from the singlet excited state (S\n                    <jats:sub>1<\/jats:sub>\n                    ) to the triplet state (T\n                    <jats:sub>1<\/jats:sub>\n                    ). The resulting increase in the T\n                    <jats:sub>1<\/jats:sub>\n                    exciton augmented both charge and energy transfer, leading to a marked enhancement in type\u2010I and type\u2010II ROS production. Consequently, PFN\u2010Br as ROS amplifier within the bulk heterostructure, disrupting intracellular redox homeostasis and activating both apoptotic and pyroptotic cell death pathways to achieve pronounced antitumor efficacy. This study offers new strategic insights for advancing high\u2010performance photocatalytic tumor therapy toward clinical application.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71356","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:26:52Z","timestamp":1781692012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["NIR\u2010Triggered Organic Semiconductor Bulk Heterostructure Nanoparticles Enable Dual\u2010Mechanism Photodynamic Anti\u2010Tumor Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Ying","family":"Huang","sequence":"first","affiliation":[{"name":"School of Pharmacy Shandong Second Medical University  Weifang Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shida","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shandong Second Medical University  Weifang Shandong P. R. 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