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This design enables the construction of a supramolecular nanoassembly (\n                    <jats:bold>GCPP5<\/jats:bold>\n                    \u2283\n                    <jats:bold>CFZ<\/jats:bold>\n                    \u2283\n                    <jats:bold>EsY\u2010CN<\/jats:bold>\n                    ) for multimodal treatment of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ) infections. The system integrates a membrane\u2010targeting\n                    <jats:bold>GCP<\/jats:bold>\n                    group, the antibiotic cefazolin (\n                    <jats:bold>CFZ<\/jats:bold>\n                    ), and a photosensitizer eosin Y derivative (\n                    <jats:bold>EsY\u2010CN<\/jats:bold>\n                    ) via host\u2010guest interactions, including the binding of\n                    <jats:bold>CFZ<\/jats:bold>\n                    to the nitrogen sites on the\n                    <jats:bold>GCP<\/jats:bold>\n                    moieties and the encapsulation of\n                    <jats:bold>EsY\u2010CN<\/jats:bold>\n                    within the electron\u2010rich cavity of the pillar[5]arene. These programmed interactions realize a multimodal \u201ctargeting\u2010chemical inhibition\u2010photodynamic oxidation\u201d antibacterial strategy. Experimental results show that the photoactivated assembly effectively generates reactive oxygen species, eradicates\n                    <jats:italic>S. aureus<\/jats:italic>\n                    at extremely low concentrations (5 to 10\u00a0n\n                    <jats:sc>m<\/jats:sc>\n                    ), inhibits and eliminates biofilms, and mitigates the increase in the minimum inhibitory concentration during serial\u2010passage assays under the tested conditions. In vivo wound models confirm that the nanoassembly could accelerate the healing process and reduce bacterial load while exhibiting good biocompatibility. By exploiting an orthogonal supramolecular design, this work establishes a promising multimodal antimicrobial strategy for combating light\u2010accessible biofilm\u2010associated infections.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71366","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T11:30:14Z","timestamp":1782127814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Orthogonal Design of a Guanidinocarbonyl Pyrrole\u2010Functionalized Pillar[5]arene\u2010Based Adjuvant for Synergistic Antibacterial Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Yutong","family":"Xie","sequence":"first","affiliation":[{"name":"College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics  Nanjing P. R. 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