{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:03:24Z","timestamp":1785240204177,"version":"3.55.0"},"reference-count":216,"publisher":"Wiley","issue":"28","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170915"],"award-info":[{"award-number":["32170915"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172931"],"award-info":[{"award-number":["82172931"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Engineered neutrophils, modified via advanced biotechnological tools, are emerging as pivotal agents in translational medicine. By integrating gene editing (e.g., CRISPR\u2010Cas9), nanotechnology, and artificial intelligence (AI), these cells are redefining precision diagnostics and therapeutics. Gene editing enables precise reprogramming to enhance tumor\u2010targeting, antimicrobial activity, and immune modulation. Nanotechnology facilitates neutrophil\u2010bound drug delivery, improving targeting to inflamed or tumor sites while reducing off\u2010target effects. Simultaneously, AI\u2010driven platforms analyze multi\u2010omics data to optimize engineering strategies and personalize treatments. These innovations demonstrate significant promise across clinical domains: in oncology, they deliver cytotoxic payloads and remodel the tumor microenvironment; in infectious diseases, they enhance pathogen clearance; and in autoimmune disorders, they dampen aberrant inflammatory responses. Despite this progress, challenges including off\u2010target edits, short in vivo persistence, and immune rejection persist. The convergence of microfluidics and high\u2010throughput screening, coupled with AI\u2010driven monitoring, is essential to accelerate clinical translation. As interdisciplinary collaboration deepens, engineered neutrophils stand at the forefront of next\u2010generation medicine, offering versatile, patient\u2010tailored strategies to bridge the gap between bioengineering breakthroughs and clinical reality.<\/jats:p>","DOI":"10.1002\/adhm.71370","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T09:11:08Z","timestamp":1781946668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineered Neutrophils in Translational Medicine: Gene Editing, Nanotechnology, and AI\u2010Driven Clinical Breakthroughs"],"prefix":"10.1002","volume":"15","author":[{"given":"Jingru","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of Nantong University Medical School of Nantong University  Nantong China"},{"name":"School of Ocean and Tropical Medicine The Second Affiliated Hospital of Guangdong Medical University Guangdong Medical University  Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of Nantong University Medical School of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subinuer","family":"Aikebaier","sequence":"additional","affiliation":[{"name":"School of Ocean and Tropical Medicine The Second Affiliated Hospital of Guangdong Medical University Guangdong Medical University  Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youcai","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Ocean and Tropical Medicine The Second Affiliated Hospital of Guangdong Medical University Guangdong Medical University  Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1737-3386","authenticated-orcid":false,"given":"Xiao","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Ocean and Tropical Medicine The Second Affiliated Hospital of Guangdong Medical University Guangdong Medical University  Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6120-7318","authenticated-orcid":false,"given":"Xiaoling","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of Nantong University Medical School of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.4c00173"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00787-0"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000558"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1BM00127B"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.01.022"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.070487"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37872-4"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-018-0254-4"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.71064"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202006484"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401513"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-022-01161-w"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00832-3"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2006.02.004"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.097"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12440"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22548-8"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0054-z"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-02006-5"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.11.011"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-12-844605"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106454"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.07.007"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09807-0"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-025-01731-0"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.12.003"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58550-7"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-025-01210-8"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.02.005"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02680"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3399"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5NR01489A"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.07.004"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-844530"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70368"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222-023-00119-4"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.162"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.895216"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-018-0024-0"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.838011"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006196"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1693809"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202404584"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004433"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2018.07.005"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1274431"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37515-8"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202003598"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aao4747"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.12.005"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-216085"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019031609"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-024-01180-z"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj2101"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.05.006"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5LC01001B"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202402768"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2023.2232146"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2018.06.007"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14963-0"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.3c00309"},{"key":"e_1_2_15_64_1","first-page":"5864","article-title":"A Pluripotential Neutrophil\u2010Mimic Nanovehicle Modulates Immune Microenvironment With Targeted Drug Delivery for Augmented Antitumor Chemotherapy","volume":"18","author":"Wu J.","year":"2024","journal-title":"ACS Nano"},{"issue":"1","key":"e_1_2_15_65_1","first-page":"101","article-title":"Modulation of Multiple Neutrophil Functions by Preparative Methods or Trace Concentrations of Bacterial Lipopolysaccharide","volume":"119","author":"Haslett C.","year":"1985","journal-title":"American Journal of Pathology"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.815412"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.816037"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S284941"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2025.105251"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111128"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c11762"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01115-9"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5c02565"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03740-0"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-024-00983-3"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5c00102"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2026.345320"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbinf.2025.1628724"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00571-6"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2023.102497"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02335-7"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99387-6"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios14070336"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312994"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007949"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1809809"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116636"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2301-5_2"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2509807"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05739-9"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2024.03.037"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.73042"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.08.015"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2025.102636"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2024.03.483"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62606-z"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1177\/17534259251365803"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1089\/10430349950018373"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196891"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05337-x"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06424-7"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17071232"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202404105"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-021-00330-7"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-019-2656-x"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00699-x"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327666201111143725"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2015.03.018"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01374-7"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56288-w"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202502200"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.41.2.378"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02753-5"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15071881"},{"key":"e_1_2_15_115_1","article-title":"Neutrophil\u2010Mimicking Nanomedicine Eliminates Tumor Intracellular Bacteria and Enhances Chemotherapy on Liver Metastasis of Colorectal Cancer","volume":"12","author":"Niu Y.","year":"2025","journal-title":"Advancement of Science"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.172209"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03806-z"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c01654"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123908"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03658-7"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-026-00744-w"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.22169"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409895"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-025-04414-4"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2025.05.009"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"issue":"1","key":"e_1_2_15_127_1","first-page":"100","article-title":"Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications","volume":"11","author":"Liu Y.","year":"2019","journal-title":"Nanomicro Letters"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaf039"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.02.033"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13619-025-00227-z"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c00734"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4NR01417K"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c02455"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202402965"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR07725B"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00027"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2025.04.010"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.90370"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b03753"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20230034"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5LC00554J"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20220001"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpx.2019.100030"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5NA00558B"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102301"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2LC00563H"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2025.107699"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303561"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/admt.202300210"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.10.010"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S563061"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aea6007"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.947657"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2025.110473"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13092171"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1012877"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03723-x"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c09066"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-025-01975-4"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios13030389"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202500984"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01422-2"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201906523"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3322"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10448"},{"key":"e_1_2_15_166_1","doi-asserted-by":"publisher","DOI":"10.1093\/jimmun\/vkae051"},{"key":"e_1_2_15_167_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM01083A"},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07250-6"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.213764"},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2019.1701141"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25897"},{"key":"e_1_2_15_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-023-00581-x"},{"key":"e_1_2_15_173_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-845-4_16"},{"key":"e_1_2_15_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113828"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.06.006"},{"key":"e_1_2_15_176_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202109969"},{"key":"e_1_2_15_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-018-0071-5"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c14487"},{"key":"e_1_2_15_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114109"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg3277"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.6563"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1808"},{"key":"e_1_2_15_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104683"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00378-6"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2022.188762"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77053"},{"key":"e_1_2_15_187_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj8207"},{"key":"e_1_2_15_188_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310318"},{"key":"e_1_2_15_189_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c04363"},{"key":"e_1_2_15_190_1","article-title":"Engineered Bacterial Outer Membrane Vesicles Hitchhiking on Neutrophils for Antibody Drug Delivery to Enhance Postoperative Immune Checkpoint Therapy","volume":"12","author":"Guan M.","year":"2025","journal-title":"Advancement of Science"},{"key":"e_1_2_15_191_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202207456"},{"key":"e_1_2_15_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4294"},{"key":"e_1_2_15_193_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2024.2431687"},{"key":"e_1_2_15_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.02.017"},{"key":"e_1_2_15_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00834-4"},{"key":"e_1_2_15_196_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c08600"},{"key":"e_1_2_15_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iotech.2023.100411"},{"key":"e_1_2_15_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2025.06.017"},{"key":"e_1_2_15_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.02.057"},{"key":"e_1_2_15_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2025.02.022"},{"key":"e_1_2_15_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801419"},{"key":"e_1_2_15_202_1","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiaf086"},{"key":"e_1_2_15_203_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03965-z"},{"key":"e_1_2_15_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48838-5"},{"key":"e_1_2_15_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109823"},{"key":"e_1_2_15_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.09.026"},{"key":"e_1_2_15_207_1","first-page":"371","article-title":"Cationic Additives in Nanosystems Activate Cytotoxicity and Inflammatory Response of Human Neutrophils: Lipid Nanoparticles Versus Polymeric Nanoparticles","volume":"10","author":"Hwang T. L.","year":"2015","journal-title":"International Journal of Nanomedicine"},{"key":"e_1_2_15_208_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14112463"},{"issue":"3","key":"e_1_2_15_209_1","first-page":"78","article-title":"Long\u2010Term Follow\u2010Up of Patients Receiving Cell and Gene Therapy Products","volume":"37","author":"Irinyi L.","year":"2026","journal-title":"Human Gene Therapy"},{"key":"e_1_2_15_210_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.02.38"},{"key":"e_1_2_15_211_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c03811"},{"key":"e_1_2_15_212_1","doi-asserted-by":"publisher","DOI":"10.34133\/2022\/9830627"},{"key":"e_1_2_15_213_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c07798"},{"key":"e_1_2_15_214_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460751.2025.2580888"},{"key":"e_1_2_15_215_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.18977"},{"key":"e_1_2_15_216_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.050947"},{"key":"e_1_2_15_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2023.08.003"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71370","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71370","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:24:30Z","timestamp":1785237870000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,20]]},"references-count":216,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/adhm.71370"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71370","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,20]]},"assertion":[{"value":"2025-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71370"}}