{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:03:02Z","timestamp":1785240182221,"version":"3.55.0"},"reference-count":64,"publisher":"Wiley","issue":"28","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470988"],"award-info":[{"award-number":["82470988"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Periodontitis is an inflammatory and destructive condition, conventional therapies yield inadequate long\u2010term efficacy and possess limited regenerative potential, while the diseased microenvironment driven by inflammation and oxidative stress further hampers tissue repair. Crucially\u200c, because of the unique nature of the periodontal microenvironment, limitations still exist, such as a short drug retention period and low drug delivery efficiency. To overcome these limitations, we developed a new nanoplatform designed to improve local drug retention and target the core pathological mechanisms of periodontitis. Comprising cyclic Arg\u2010Gly\u2010Asp (cRGD) modified Zeolitic Imidazolate Framework\u20108 (ZIF\u20108) and loaded with the dual\u2010action agent Syringic Acid (SA), these nanoparticles create a local drug reservoir through enhanced cellular uptake, SA@ZIF\u20108\u2010cRGD showed the time\u2010sequence regulation of cellular inflammation and oxidative stress levels. This nano\u2010platform orchestrates sequential therapeutic actions: initial rapid uptake by macrophages confers anti\u2010inflammatory effects, then restores the osteogenic potential of human periodontal ligament stem cells (hPDLSCs) by decreasing oxidative stress, partly through the metallothionein protein family. In the periodontitis model, SA@ZIF\u20108\u2010cRGD significantly attenuated periodontal inflammation and promoted tissue regeneration. Collectively, our findings indicate that SA@ZIF\u20108\u2010cRGD achieves excellent periodontitis treatment outcomes by temporally regulating multiple cells across the entire anti\u2010inflammatory\u2010regenerative pathway. This unveils a promising material\u2010based strategy for managing clinical periodontitis.<\/jats:p>","DOI":"10.1002\/adhm.71377","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:20:26Z","timestamp":1782883226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathology\u2010Targeted Nanoparticles Guided by Peptide Remodel the Periodontal Microenvironment for Periodontitis Therapy"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-1524","authenticated-orcid":false,"given":"Hongning","family":"Wang","sequence":"first","affiliation":[{"name":"The Affiliated Stomatological Hospital of Chongqing Medical University  Chongqing P. R China"},{"name":"Chongqing Key Laboratory of Oral Diseases  Chongqing P. R China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing P. R China"},{"name":"Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering  Chongqing P. R China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Miao","sequence":"additional","affiliation":[{"name":"The Affiliated Stomatological Hospital of Chongqing Medical University  Chongqing P. R China"},{"name":"Chongqing Key Laboratory of Oral Diseases  Chongqing P. R China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing P. R China"},{"name":"Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering  Chongqing P. R China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Yan","sequence":"additional","affiliation":[{"name":"The Affiliated Stomatological Hospital of Chongqing Medical University  Chongqing P. R China"},{"name":"Chongqing Key Laboratory of Oral Diseases  Chongqing P. R China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing P. R China"},{"name":"Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering  Chongqing P. R China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunke","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Affiliated Stomatological Hospital of Chongqing Medical University  Chongqing P. R China"},{"name":"Chongqing Key Laboratory of Oral Diseases  Chongqing P. R China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing P. R China"},{"name":"Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering  Chongqing P. R China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"The Affiliated Stomatological Hospital of Chongqing Medical University  Chongqing P. R China"},{"name":"Chongqing Key Laboratory of Oral Diseases  Chongqing P. R China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing P. R China"},{"name":"Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering  Chongqing P. R China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwei","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Affiliated Stomatological Hospital of Chongqing Medical University  Chongqing P. R China"},{"name":"Chongqing Key Laboratory of Oral Diseases  Chongqing P. R China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing P. R China"},{"name":"Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering  Chongqing P. R China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjing","family":"Guo","sequence":"additional","affiliation":[{"name":"The Affiliated Stomatological Hospital of Chongqing Medical University  Chongqing P. R China"},{"name":"Chongqing Key Laboratory of Oral Diseases  Chongqing P. R China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing P. R China"},{"name":"Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering  Chongqing P. R China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Ma","sequence":"additional","affiliation":[{"name":"The Affiliated Stomatological Hospital of Chongqing Medical University  Chongqing P. R China"},{"name":"Chongqing Key Laboratory of Oral Diseases  Chongqing P. R China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing P. R China"},{"name":"Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering  Chongqing P. R China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[{"name":"The Affiliated Stomatological Hospital of Chongqing Medical University  Chongqing P. R China"},{"name":"Chongqing Key Laboratory of Oral Diseases  Chongqing P. R China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing P. R China"},{"name":"Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering  Chongqing P. R China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Liu","sequence":"additional","affiliation":[{"name":"The Affiliated Stomatological Hospital of Chongqing Medical University  Chongqing P. R China"},{"name":"Chongqing Key Laboratory of Oral Diseases  Chongqing P. R China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing P. R China"},{"name":"Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering  Chongqing P. R China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximu","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Affiliated Stomatological Hospital of Chongqing Medical University  Chongqing P. R China"},{"name":"Chongqing Key Laboratory of Oral Diseases  Chongqing P. R China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing P. R China"},{"name":"Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering  Chongqing P. R China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010024\u201000910\u20105"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123713"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517693566"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103451"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13112"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12374"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12342"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12422"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1634909"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13152"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100757.2012.00455.x"},{"key":"e_1_2_8_13_1","first-page":"796","article-title":"Aggressive Periodontitis","volume":"121","author":"Siebert T.","year":"2020","journal-title":"Bratislavske Lekarske Listy"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12147"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.02.026"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj11050112"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12821"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.70015"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12630"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.09.173"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c02441"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116728"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-017-1105-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079\u2010018\u20100449\u20103"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010019\u20100514\u2010y"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202105738"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c07843"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202402335"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202309038"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c04369"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123528"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.04.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.02.008"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.11.1520"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2018.04.013"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c10213"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.04.010"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v021a27"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b01352"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5TB00802F"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123588"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c05722"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.123091"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c10037"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.09.027"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003793\u20101"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658\u2010023\u201000489\u2010y"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12224126"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157520"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2025.124018"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2025.112245"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010023\u201001729\u2010y"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.022"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c12681"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202304136"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202307133"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.12.032"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.133582"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121969"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adi9769"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00152005"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c05266"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.4"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.14106"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201098924\u2010x"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71377","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:24:17Z","timestamp":1785237857000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":64,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/adhm.71377"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71377","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"assertion":[{"value":"2026-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71377"}}