{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:52:35Z","timestamp":1786121555086,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51871246"],"award-info":[{"award-number":["51871246"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tumor nanocatalytic therapy represents a promising transformative technology for treating malignant tumors, yet is often limited by insufficient catalytic activity and adaptive tumor microenvironment (TME) resistance. Herein, we develop a plasmonic Pt\u2010CuO\n                    <jats:sub>2<\/jats:sub>\n                    nanozyme that integrates plasmonic enhancement with self\u2010sufficient H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    supply for augmented cascade catalytic therapy. The nanozyme comprises Pt nanoparticles (NPs) and CuO\n                    <jats:sub>2<\/jats:sub>\n                    nanodots co\u2010deposited on Au nanostars and encapsulated within PEGylated ZIF\u20108 metal\u2013organic frameworks (MOFs). It exhibits strong near\u2010infrared localized surface plasmon resonance, enables intrinsic H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    generation, and depletes glutathione, effectively disrupting intratumoral redox homeostasis. Under acidic TME conditions, the MOFs degrade, releasing Pt NPs and CuO\n                    <jats:sub>2<\/jats:sub>\n                    nanodots to produce \u2219OH via peroxidase\u2010like and Fenton\u2010like catalytic reactions. Plasmonic heating and \u201chot electron\u201d injection under 808\u00a0nm laser irradiation further promote \u2219OH generation. This process induces mitochondrial dysfunction, suppresses adenosine triphosphate biosynthesis and downregulates heat shock proteins, thereby increasing thermal sensitivity of cancer cells and enhancing the efficacy of mild plasmonic hyperthermia therapy (PHT). In a triple\u2010negative breast cancer murine model, the nanozyme demonstrates superior anticancer performance through the synergy of plasmon\u2010enhanced catalysis, self\u2010supplied H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , redox homeostasis disruption, and mild PHT. This study provides a novel strategy for efficient nanocatalytic therapy with substantial potential for clinical translation.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71394","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:00:27Z","timestamp":1782792027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasmonically Reinforced Self\u2010Sufficient Nanozymes Dysregulating Redox Homeostasis for Augmented Cascade Catalytic Oncotherapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Han","family":"Wang","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Central South University  Changsha Hunan 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