{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:46:13Z","timestamp":1792035973154,"version":"4.4.0"},"reference-count":111,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Electrospun hydrogels often lack sufficient mechanical integrity for biomedical applications, while nanoparticle\u2010reinforced systems are commonly associated with synthetic matrices or complex fabrication methods. Here, electrospun methacrylated alginate (AM) fibrous hydrogels reinforced with mesoporous silica nanoparticles (MSNs) are introduced as a simple, biocompatible platform for localized drug delivery. The mats are UV\u2010cross\u2010linked in ethanol to maintain fibrous morphology and allow chlorhexidine (CHX) loading from 0.2 to 5\u00a0mg ml\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    . Incorporation of 1 wt.% MSNs doubles compressive and tensile strength while reducing swelling by 25%. Fourier transform infrared spectroscopy and thermogravimetric analysis confirm CHX adsorption in mats with and without MSNs. Although both systems exhibit similar initial CHX loading, MSN\u2010containing hydrogels show prolonged antibacterial activity and higher cytotoxicity, indicating sustained CHX retention and release. Ultraviolet\u2013visible spectroscopy demonstrates reduced CHX release at higher loading in MSN\u2010reinforced mats, unlike MSN\u2010free mats, suggesting strong CHX\u2010MSN\u2010AM interactions and improved retention within MSN mesopores and the AM matrix. These findings show that MSN incorporation tunes both mechanical performance and drug release behavior, supporting localized antimicrobial delivery for wound dressings and implant coatings.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71396","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T11:02:51Z","timestamp":1782558171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tailoring Drug Release Profiles From Electrospun Alginate Fibers Through Integration of Mesoporous Silica Nanoparticles"],"prefix":"10.1002","volume":"15","author":[{"given":"Carolina Gutierrez","family":"Cisneros","sequence":"first","affiliation":[{"name":"KU Leuven Department of Materials Engineering (MTM)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinal Gaurav","family":"Srivastava","sequence":"additional","affiliation":[{"name":"KU Leuven Department of Materials Engineering (MTM)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7773-8199","authenticated-orcid":false,"given":"Naiera","family":"Zayed","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences KU Leuven  Leuven Belgium"},{"name":"Faculty of Pharmacy Menoufia University  Shebin El\u2010Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Deknudt","sequence":"additional","affiliation":[{"name":"KU Leuven Department of Materials Engineering (MTM)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7675-5643","authenticated-orcid":false,"given":"Wim","family":"Teughels","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel","family":"Braem","sequence":"additional","affiliation":[{"name":"KU Leuven Department of Materials Engineering (MTM)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4339-8827","authenticated-orcid":false,"given":"Arn","family":"Mignon","sequence":"additional","affiliation":[{"name":"KU Leuven Department of Materials Engineering (MTM)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ad1bb1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14070789"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42765-022-00198-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.09.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA07559E"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37288"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.1c00116"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr9010137"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16040469"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16081017"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-024-00576-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/polb.22359"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/176015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1JM13811A"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.115049"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(01)00248-6"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202507209"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.06.003"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.02.012"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2021.1876053"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.5958\/0974-360X.2016.00353.X"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-022-04403-w"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10101192"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1086\/657134"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-024-05643-0"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12887"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2015.11.015"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2021.102865"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobe.2024.111528"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.06.163"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/jcis.2001.7471"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.0c00729"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-023-05688-4"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano12193308"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4TB00499J"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13060845"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9050574"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym11020275"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR07406C"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-020-0227-7"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels9060439"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116995"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13784"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8790143"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b08255"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym16070869"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10100638"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17100557"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2022.02.052"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA15232H"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.202400229"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA03733H"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA02166B"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB02511F"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1987.tb01531.x"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102361"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering4030059"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c09164"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2016.09.055"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2015.08.138"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-006-8318-3"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16030377"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13172897"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123017"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2024.2359483"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02419-14"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2019.10.021"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn325"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1086\/667371"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242004000300012"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2025.106330"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10847-019-00920-y"},{"key":"e_1_2_8_74_1","first-page":"1408","article-title":"Graft Copolymerization of Methyl Methacrylate onto Alginate Using Benzoyl Peroxide Initiator","volume":"6","author":"Salisu A.","year":"2015","journal-title":"Research Journal of Pharmaceutical, Biological and Chemical Sciences"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.0c04602"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep06064"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bsecv.2017.03.002"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.08.027"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.09.031"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.11.081"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oor.2024.100245"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104305"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJPHARM.2024.124654"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.14440\/jbm.2015.73"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689719825614"},{"key":"e_1_2_8_86_1","unstructured":"Abcam \u201cCalcein AM Staining: A Guide To Cell Viability \u201d accessed2025 https:\/\/www.abcam.com\/en\u2010us\/knowledge\u2010center\/cell\u2010biology\/calcein\u2010am\u2010staining."},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj12070221"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb13040280"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076349"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.829796"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics9020049"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555817435.ch5"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir1061"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.3389\/FCIMB.2024.1352273"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12091414"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2022.01.005"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13229"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12747"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.3389\/fdmed.2021.779852"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.24622"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA23435B"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.11.051"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32191"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.03.040"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2023.112137"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym15244685"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.08.102"},{"key":"e_1_2_8_108_1","unstructured":"M.KGaA \u201cPhosphate Buffered Saline \u201d accessed2025 https:\/\/www.sigmaaldrich.com\/BE\/en\/product\/sigma\/p4417?utm_source=google&utm_medium=cpc&utm_campaign=21791215847&utm_content=171640281794&gad_source=1&gclid=CjwKCAiAzvC9BhADEiwAEhtlNwWir7V3mvlerFJOk6iZONhrIH_SkLhD9JW0LbY8mcX6kIUxXuBCJRoCgk4QAvD_BwE."},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.23-0674"},{"key":"e_1_2_8_110_1","unstructured":"S.TermoFisher \u201cLIVE\/DEADTM Viability\/Cytotoxicity Kit for mammalian cells \u201d accessed2024 https:\/\/www.thermofisher.com\/order\/catalog\/product\/L3224."},{"key":"e_1_2_8_111_1","first-page":"126","volume-title":"Handbook Of Biological Statistics","author":"McDonald J. H.","year":"2014"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1093\/beheco\/ark016"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71396","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71396","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T05:42:02Z","timestamp":1786081322000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,27]]},"references-count":111,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/adhm.71396"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71396","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,27]]},"assertion":[{"value":"2026-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71396"}}