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Here, we present an injectable, in situ\u2010forming multifunctional hydrogel designed to treat these failure modes as one integrated interface problem rather than three separate ones. The hydrogel combines dopamine\u2010grafted sodium alginate (SA\u2010DA) and branched poly(ethylene imine) (PEI) in a charge\u2010balanced pseudozwitterionic macromolecular network that resists nonspecific protein adsorption while providing catechol\u2010mediated wet adhesion. Through dual macromolecular crosslinking, the hydrogel undergoes rapid gelation under surgically compatible conditions, conformally seals dural defects, fills interfacial gaps, and provides wet tissue adhesion without relying on diffusible small\u2010molecule monomers. When integrated with a 128\u2010channel flexible micro\u2010ECoG mesh array, this platform reduced glial activation and fibrotic encapsulation and preserved stable, high\u2010fidelity cortical recordings over a 3\u2010week early\u2010chronic period. More broadly, this study establishes a design principle for sustained soft bioelectronics: long\u2010term function can be improved by co\u2010engineering barrier restoration, interfacial adhesion, and antifouling protection within a single interface material.<\/jats:p>","DOI":"10.1002\/adhm.71397","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:16:20Z","timestamp":1782731780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Injectable Antifouling Adhesive Hydrogel Enables Robust Neural Interfaces for Stable ECoG Recording"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiacheng","family":"Peng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of Technology  Wuhan 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College of Life Science and Technology Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine Research Center for Intelligent Fiber Devices and Equipment State Key Laboratory of New Textile Materials and Advanced Processing College of Life Science and Technology Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3703-2842","authenticated-orcid":false,"given":"Bing","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Brain Atlas and Brain\u2010inspired Intelligence Institute of Automation Chinese Academy of Sciences Beijing 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