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However, the hypoxic\/anaerobic microenvironment within periodontal pockets significantly restricts the antibacterial efficacy and clinical translatability of oxygen\u2010dependent radical therapy. By conjugating gold nanorods (AuNRs) with carboxylatopillar[5]arene (CP5), followed by the loading of 2,2'\u2010azobis[2\u2010(2\u2010imidazolin\u20102\u2010yl)propane] dihydrochloride (AIPH) via host\u2013guest recognition interactions, we develop an oxygen\u2010independent radical delivery nanoplatform (AIPH\u2282CP5\u2010AuNR) to overcome the abovementioned barrier. Upon 808 nm near\u2010infrared (NIR) irradiation, AuNRs induce localized photothermal effects that not only disrupt bacterial biofilms via photothermal therapy (PTT) but also trigger the thermal decomposition of AIPH to generate oxygen\u2010independent alkyl radicals, thereby enabling thermodynamic therapy (TDT). Both in vitro and in vivo studies demonstrate that the cascaded PTT\/TDT approach effectively eradicates pathogenic biofilms and alleviates periodontitis in rat models. This study not only proposes a novel oxygen\u2010independent therapeutic strategy but also expands the biomedical applications of supramolecular nanomaterials in stimuli\u2010responsive drug delivery.<\/jats:p>","DOI":"10.1002\/adhm.71399","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:23:13Z","timestamp":1782973393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxygen\u2010Independent Supramolecular Nanoplatform for Photothermal\u2010Thermodynamic Therapy Against Periodontal Anaerobic Infections"],"prefix":"10.1002","volume":"15","author":[{"given":"Hong\u2010Pu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering School and Hospital of Stomatology Jilin University  Changchun P. R. 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