{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T02:55:26Z","timestamp":1786589726370,"version":"build-2736575974"},"reference-count":73,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Developing biomaterials that simultaneously support tissue repair while inhibiting infection remains a critical challenge in wound\u2010healing research. Here, a novel series of D\u2010amino acid and D\/L\u2010hybrid analogs has been synthesized to investigate the influence of stereochemistry on wound healing and antimicrobial activity. Self\u2010assembly into a nanofibrous network enables these peptides to form hydrogels that serve as injectable, biomimetic scaffolds for drug delivery and antimicrobials, making them ideal for advanced wound\u2010healing applications. Molecular docking revealed the strongest binding affinity of AN2D3 peptide toward integrin \u03b1v\u03b23, suggesting it as a promising lead candidate for targeting \u03b1v\u03b23\u2010mediated pathways in cell adhesion and proliferation. Further, these peptides are systematically evaluated in methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA)\u2010infected Balb\/c mice to assess their antimicrobial activity, mechanical integrity, and regenerative potential. Remarkably, as the D\u2010amino acid content increased in the sequences, antimicrobial efficacy and wound\u2010healing also improved. Among peptide sequences, AN2D3 yielded the best results, highlighting the critical role of stereochemistry in peptide\u2010based constructs. These hydrogels were designed to resist enzymatic degradation while promoting interactions with the extracellular matrix and innate antimicrobial activity. This inversion of stereochemistry is anticipated to influence the bioactivity of the peptide hydrogels, suggesting that even subtle shifts in chirality may affect biomaterial behavior.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71401","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:18:53Z","timestamp":1782973133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioactive Hydrogels with D\u2010Amino Acid RGD Mimics: A Therapeutic Strategy for Expeditious Infected Wound Closure"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7275-6188","authenticated-orcid":false,"given":"Akanksha","family":"Negi","sequence":"first","affiliation":[{"name":"Nucleic Acids Research Laboratory CSIR\u2010Institute of Genomics and Integrative Biology Delhi India"},{"name":"Department of Biomedical Science Acharya Narendra Dev College  New Delhi India"},{"name":"Dr. B.R. Ambedkar Center For Biomedical Research University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Yadav","sequence":"additional","affiliation":[{"name":"Nucleic Acids Research Laboratory CSIR\u2010Institute of Genomics and Integrative Biology Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha","family":"Jain","sequence":"additional","affiliation":[{"name":"Nucleic Acids Research Laboratory CSIR\u2010Institute of Genomics and Integrative Biology Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Goel","sequence":"additional","affiliation":[{"name":"Nucleic Acids Research Laboratory CSIR\u2010Institute of Genomics and Integrative Biology Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant Kumar","family":"Gautam","sequence":"additional","affiliation":[{"name":"Nucleic Acids Research Laboratory CSIR\u2010Institute of Genomics and Integrative Biology Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0547-3336","authenticated-orcid":false,"given":"Vijay Pal","family":"Singh","sequence":"additional","affiliation":[{"name":"Nucleic Acids Research Laboratory CSIR\u2010Institute of Genomics and Integrative Biology Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagan","family":"Dhawan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science Acharya Narendra Dev College  New Delhi India"},{"name":"School of Allied Medical Sciences Delhi Skill and Entrepreneurship University  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunit K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Dr. B.R. Ambedkar Center For Biomedical Research University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwani Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Nucleic Acids Research Laboratory CSIR\u2010Institute of Genomics and Integrative Biology Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5874-8191","authenticated-orcid":false,"given":"Pradeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Nucleic Acids Research Laboratory CSIR\u2010Institute of Genomics and Integrative Biology Delhi India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003053"},{"key":"e_1_2_9_3_1","article-title":"The Increasing Problem of Wound Bacterial Burden and Infection in Acute and Chronic Soft\u2010Tissue Wounds Caused by Methicillin\u2010Resistant Staphylococcus Aureus","volume":"7","author":"Demling R. 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