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Mesenchymal stromal cell extracellular vesicles (MSC\u2010EVs) have immunomodulatory and regenerative activity, which can be enhanced by cytokine licensing of MSCs with TGF\u2010\u03b21 and IFN\u2010\u03b3. A key barrier is achieving sustained, localized ocular delivery. Here, we combine licensed MSC\u2010EVs with a gellan gum fluid gel (FG), a biocompatible, shear\u2010thinning viscoelastic system designed to improve residence time versus conventional eyedrops. Licensed MSC\u2010EVs were isolated by size\u2010exclusion chromatography and characterized by morphology, size, and marker expression. FG was produced by shear gelation and assessed for transparency, rheology, EV release, and cytocompatibility. EVs were spherical (102\u00a0nm) and expressed CD9, CD63, CD81, and TSG101. FG behaved as solid at rest and flowed under shear. The lead formulation released 18% of loaded EVs over 6\u00a0h, significantly outperforming comparator gels (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001), and was non\u2010toxic to human corneal epithelial cells and keratocytes. Released EVs accelerated closure in an in vitro corneal wound model and reduced epithelial defect and inflammation in a traumatic LSCD model in vivo. Gellan gum FG therefore enables controlled MSC\u2010EV delivery and shows promise for treating severe corneal disease.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71402","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T02:17:34Z","timestamp":1782872254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gellan Gum Fluid Gel System for Controlled\u2010Delivery of Cytokine\u2010Licensed MSC\u2010EVs to Enhance Corneal Repair in Limbal Stem Cell Deficiency"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7414-3248","authenticated-orcid":false,"given":"Seyedmohammad","family":"Moosavizadeh","sequence":"first","affiliation":[{"name":"Regenerative Medicine Institute (REMEDI), Discipline of Advanced Therapies School of Medicine University of Galway Galway Ireland"},{"name":"Research Ireland Centre For Medical Devices (CURAM) University of Galway  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7146-5167","authenticated-orcid":false,"given":"Ava","family":"Dashti","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Healthcare Technologies Institute School of Chemical Engineering University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Gaffey","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Institute (REMEDI), Discipline of Advanced Therapies School of Medicine University of Galway Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Moakes","sequence":"additional","affiliation":[{"name":"Healthcare Technologies Institute School of Chemical Engineering University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1079-4361","authenticated-orcid":false,"given":"Neil","family":"Lagali","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9774-7412","authenticated-orcid":false,"given":"Liam","family":"Grover","sequence":"additional","affiliation":[{"name":"Healthcare Technologies Institute School of Chemical Engineering University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7709-8489","authenticated-orcid":false,"given":"Thomas","family":"Ritter","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Institute (REMEDI), Discipline of Advanced Therapies School of Medicine University of Galway Galway Ireland"},{"name":"Research Ireland Centre For Medical Devices (CURAM) University of Galway  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108137"},{"key":"e_1_2_9_3_1","first-page":"7","volume-title":"Progress in Molecular Biology and Translational Science","author":"Eghrari A. 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