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Although photothermal therapy (PTT) and gas therapy (e.g., CO, H\n                    <jats:sub>2<\/jats:sub>\n                    ) are promising alternatives to conventional antibiotics, existing monotherapeutic strategies fail to address the multifactorial pathological characteristics of these wounds, which is a critical research gap. To fill this gap, an integrated multimodal nanoplatform (CO\/AB@MPDA) by co\u2010loading dodecacarbonyltriiron (FeCO, a CO donor) and ammonia borane (AB, a H\n                    <jats:sub>2<\/jats:sub>\n                    donor) into mesoporous polydopamine (MPDA) carriers was developed. The innovation lied in its synergistic design. It enabled near\u2010infrared (NIR)\u2010triggered CO release and pH\u2010responsive H\n                    <jats:sub>2<\/jats:sub>\n                    generation, simultaneously targeting infections, inflammation, and microenvironment dysregulation. In vitro and in vivo experiments confirmed its potent antibacterial\/biofilm\u2010disrupting activity, high biosafety, reactive oxygen species (ROS) scavenging, anti\u2010inflammatory properties, as well as superior ability to accelerate diabetic infected wound healing. In summary, the CO\/AB@MPDA nanosystem overcomes the limitations of monomodal therapies through synergistic PTT\u2010gas therapy, providing an innovative and comprehensive therapeutic strategy for diabetic wound infections.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71403","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:21:16Z","timestamp":1782973276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An All\u2010in\u2010One Nanoplatform for Synergistic Anti\u2010Infection and Healing of Diabetic Wounds via Photothermal\u2010Gas Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Shaopeng","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology College of Bioengineering Ministry of Education Chongqing University  Chongqing 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