{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:51:00Z","timestamp":1786121460482,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M762373"],"award-info":[{"award-number":["2024M762373"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472322"],"award-info":[{"award-number":["32472322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The rise of multidrug\u2010resistant bacterial infections and biofilms poses a significant challenge to wound healing. Herein, we developed a temperature\u2010responsive gel\u2013sol phase\u2010transition multifunctional hydrogel, named CPAM\/GS, by incorporating a novel nanozyme, CeO\n                    <jats:sub>2<\/jats:sub>\n                    @PtAu@Mn\n                    <jats:sub>2<\/jats:sub>\n                    (CO)\n                    <jats:sub>10<\/jats:sub>\n                    , into a gelatin\/sodium alginate matrix. The synthesized CeO\n                    <jats:sub>2<\/jats:sub>\n                    @PtAu@Mn\n                    <jats:sub>2<\/jats:sub>\n                    (CO)\n                    <jats:sub>10<\/jats:sub>\n                    nanozyme exhibits multi\u2010enzyme activities, including peroxidase\u2010, oxidase\u2010, and catalase\u2010like properties, enabling it to generate ROS in response to the pH of the infected microenvironment and supply oxygen under hypoxic conditions. The CPAM\/GS hydrogel demonstrates excellent photothermal performance (\u03b7 = 47.99%) and allows on\u2010demand release of carbon monoxide (CO) and nanozymes upon NIR irradiation. In vitro experiments confirmed its potent antibacterial efficacy against methicillin\u2010resistant Staphylococcus aureus and Pseudomonas aeruginosa through the synergistic effects of photothermal therapy, chemodynamic therapy, and CO gas therapy, achieving a 100% and 99.8% antibacterial rate under NIR irradiation. Furthermore, this hydrogel effectively disrupts preformed biofilms, suppresses virulence gene expression, and promotes cell migration. In a mouse model of MRSA\u2010infected wounds, treatment with CPAM\/GS hydrogel\u2010NIR\n                    <jats:sub>(+)<\/jats:sub>\n                    significantly accelerated wound healing, eliminated bacteria, and modulated wound microenvironment by reducing pro\u2010inflammatory cytokines and promoting angiogenesis. Its excellent biosafety and hemostatic performance were also confirmed. This work proposes a multifunctional synergistic strategy for treating multidrug\u2010resistant bacterial infections and promoting wound regeneration.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71404","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:55:34Z","timestamp":1783756534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NIR\u2010Triggered On\u2010Demand Synergistic Therapy for Multidrug\u2010Resistant Bacterial Infections Via a Smart Phase\u2010Transition Hydrogel"],"prefix":"10.1002","volume":"15","author":[{"given":"Ting","family":"Du","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin P. R. 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