{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:35:53Z","timestamp":1786700153246,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2409803"],"award-info":[{"award-number":["2022YFC2409803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071330"],"award-info":[{"award-number":["32071330"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Rotator cuff tears are highly prevalent among elderly individuals and athletes. They often lead to persistent pain and restricted mobility, and frequently necessitate surgical intervention. Despite advances in repair techniques, the reattachment of tendon to bone remains a major clinical challenge, with high failure rates primarily attributed to poor regeneration of the tendon\u2010to\u2010bone interface. In this study, we evaluated a collagen\u2010based porous scaffold to support tendon\u2010to\u2010bone healing after rotator cuff repair. First, analysis of public transcriptomic datasets from human lesional tendons identified a \u201cfailed healing\u201d state characterized by disorganized fibrosis and activation of inflammatory pathways. Subsequently, MC3T3\u2010E1 and TTD6 cells were cultured on the scaffold to evaluate scaffold\u2010cell interactions. Transcriptomic analysis was performed to explore scaffold\u2010associated cellular responses, and the results suggested changes related to matrix interaction, cell adhesion, and repair\u2010associated remodeling. To evaluate the in vivo performance, a rotator cuff repair model in beagle dogs was established, and the scaffold was implanted at the injury site. Magnetic resonance imaging, biomechanical testing, and histological analyses showed improved tissue integration, mechanical performance, and histological organization. These findings suggest that the scaffold may support tendon\u2010to\u2010bone healing and has translational potential as a collagen\u2010based augmentation patch for rotator cuff repair.<\/jats:p>","DOI":"10.1002\/adhm.71405","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:28:01Z","timestamp":1783052881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Collagen\u2010based Scaffold Supports Tendon\u2010to\u2010bone Healing After Rotator Cuff Repair: An Integrated Translational Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2284-1866","authenticated-orcid":false,"given":"Zhanhong","family":"Liu","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Biomaterials Sichuan University  Chengdu China"},{"name":"College of Biomedical Engineering Sichuan University  Chengdu 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