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MSC\u2010derived EVs have emerged as promising therapeutic candidates for osteoarthritis (OA) because they carry bioactive molecules, are easily delivered, and exhibit low immunogenicity. In this study, we generated MSCs with altered cell fate by transferring the microenvironment of SW982 human synovial fibroblast\u2010like cells through direct MSC\u2013synovial fibroblast (SF) interaction and evaluated EVs derived from these cells (miSF\u2010MSC\u2010EVs) as a therapeutic strategy for OA. MSCs and SFs were stained with nuclear dyes, co\u2010cultured for 48\u00a0h, and double\u2010positive cells were isolated by fluorescence\u2010activated cell sorting. Proteomic and next\u2010generation sequencing analyses revealed enrichment of miRNAs associated with cell migration, adhesion, and transforming growth factor\u2010\u03b2, Wnt, and PI3K signaling pathways in miSF\u2010MSC\u2010EVs. Compared with conventional MSC\u2010EVs, miSF\u2010MSC\u2010EVs enhanced cell proliferation, improved regenerative responses, reduced inflammatory marker expression, and increased anti\u2010inflammatory marker expression in vitro. Furthermore, miSF\u2010MSC\u2010EVs promoted cartilage repair in a mouse OA model, highlighting their potential as a regenerative therapeutic platform for OA treatment.<\/jats:p>","DOI":"10.1002\/adhm.71406","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:04:54Z","timestamp":1783400694000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic Extracellular Vesicles from Synovial Fibroblast\u2010Primed MSCs for Osteoarthritis Treatment"],"prefix":"10.1002","volume":"15","author":[{"given":"Seo Jeong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biomedical Systems Science, College of Biomedical Science Kangwon National University  Chuncheon\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Seob","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Systems Science, College of Biomedical Science Kangwon National University  Chuncheon\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hee","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Systems Science, College of Biomedical Science Kangwon National University  Chuncheon\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Hyeok","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Systems Science, College of Biomedical Science Kangwon National University  Chuncheon\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Sun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Systems Science, College of Biomedical Science Kangwon National University  Chuncheon\u2010si Republic of 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