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Although ROS\u2010based photocatalysis and nanozyme catalysis are promising, single\u2010component systems are often limited by charge\u2010carrier recombination, low ROS generation efficiency, and slow reaction kinetics. Herein, we report a porous C\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>4<\/jats:sub>\n                    @oxygen\u2010vacancy\u2010rich CoFe\u2010LDH quantum\u2010dot (p\u2010CN@CF\u2010O) composite heterostructure, in which ultrasmall CoFe\u2010LDH quantum dots are uniformly anchored onto the surface of porous C\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>4<\/jats:sub>\n                    (p\u2010CN), forming robust and intimate heterointerfaces. The defect\u2010rich p\u2010CN framework facilitates charge transport and reactant adsorption, while oxygen vacancies in the CoFe\u2010LDH quantum dots markedly enhance peroxidase\u2010like activity and promote interfacial charge separation. The cooperative effect of multilevel defects significantly boosts ROS generation, enabling highly efficient antibacterial activity under mild conditions. Moreover, the composite serves as a micro\u2010scaffold that supports epidermal cell proliferation and migration. In a skin infection model in vivo, this material effectively eradicates bacteria, suppresses biofilm formation, and accelerates wound healing, demonstrating outstanding potential for skin anti\u2010infective therapy. This work not only establishes an efficient photocatalysis\u2010nanozyme synergistic antibacterial strategy, but also provides valuable insights into the rational design and mechanistic understanding of heterostructured antibacterial materials.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71418","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:16:24Z","timestamp":1784096184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Defect\u2010Engineered Porous C\n                    <sub>3<\/sub>\n                    N\n                    <sub>4<\/sub>\n                    \/CoFe\u2010LDH Quantum Dot Heterostructures for Synergistic Photocatalytic\u2010Nanozyme Antibacterial Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Longwei","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy Shandong Medical And Pharmaceutical University Yantai P. 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