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Frequently utilized lifting agents include saline, starch, ORISE Gel, Eleview, EverLift, BlueBoost and EndoClot SIS. In this context, we have formulated a sodium alginate\u2010based lifting gel incorporating biocompatible methylene blue dye, which significantly enhances lesion visualization and delineation. Our Na alginate\u2010derived lifting hydrogels displayed favorable shear\u2010thinning characteristics, with an elevated viscosity (44\u2013190 mPa\u2219s) at lower shear rates compared to commercially available lifting agents (1.7\u201344 mPa\u2219s). In lyophilized form, it exhibited short reconstitution time (60\u201390 s), near physiological pH (\u223c6.5), and osmolality (265\u2013275 mOsm\/kg). Ex vivo assessments validated the sustained lift height and cushion circumference for 60 min, while in vivo investigations in swine illustrated successful injectability, cushion retention for 45 min, and an absence of adverse tissue reactions. The goal was to investigate the relationship between rheological properties and mucosal lifting performance. By integrating prolonged elevation, improved visualization, biocompatibility, and optimal physicochemical characteristics, our alginate\u2010based lifting gel effectively addresses the limitations inherent in previous agents, offers a more efficient, and versatile next\u2010generation lifting agent for EMR and ESD.<\/jats:p>","DOI":"10.1002\/adhm.71427","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T16:48:46Z","timestamp":1783788526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sodium Alginate\u2010Based Submucosal Lifting Hydrogel for Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2706-8481","authenticated-orcid":false,"given":"Iram","family":"Maqsood","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Maryland School of Pharmacy  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata S.","family":"Akshintala","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya T.","family":"Evani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Krimins","sequence":"additional","affiliation":[{"name":"Russell H. 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