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Herein, ferric iron\u2010chelated silk fibroin microfibers (Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010mSF) are explored as a magnetic nanoparticle\u2010free alternative to existing magneto\u2010responsive fiber architectures. Functionalization of nascent mSF via iron chelation exhibited stability at physiological pH, with minimal iron release observed over 7\u2010d and 3\u2010month periods. Mechanically, the addition of Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010mSF to an existing injectable, in situ crosslinking hydrogel did not compromise its injectability, gelation kinetics, or low swelling profile. Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010mSF cytocompatibility was observed in SH\u2010SY5Y cells (neuronal analog), both when cultured with Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010mSF\u2010supplemented media and when cultured within Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010mSF\/collagen hydrogels, and the addition of Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010mSF to a collagen\u2010only hydrogel resulted in a few significant changes in neuroregenerative biomarker expression. Finally, in a proof\u2010of\u2010principle study, magnetically\u2010actuated alignment of Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010mSF\/hydrogel composites was achieved on the patient bed of a magnetic resonance imaging (MRI) machine, without obvious pulling of the fiber architecture from the hydrogel bulk. It is envisioned that this Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010mSF\u2010laden hydrogel system may be used as an injectable, in situ aligning neuroregenerative scaffold.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71430","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:25:37Z","timestamp":1783941937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Iron\u2010Chelated Silk Microfiber\/Hydrogel Composites as Injectable, Magnetically Aligned Cell Guidance Scaffolds"],"prefix":"10.1002","volume":"15","author":[{"given":"Melissa A.","family":"Wojnowski","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Worcester Polytechnic Institute  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zephyr 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