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Additive manufacturing (AM) technologies present new strategies to overcome these hurdles by enabling precise control over biomaterial composition, microarchitecture, and spatial organization across three pipeline areas: EV production, isolation and purification, and scaffold\u2010based delivery. This review examines AM applications across those EV production pipeline nodes. We analyze how AM variables \u2014 matrix stiffness, scaffold geometry, shear conditions, and crosslinking chemistry \u2014 affect EV yield, cargo composition, membrane integrity, and functional potency. By linking engineering approaches with biological considerations, we highlight AM's potential to unify manufacturing efficiency with therapeutic performance, while addressing limitations in throughput, standardization, and translational readiness.<\/jats:p>","DOI":"10.1002\/adhm.71439","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:00:33Z","timestamp":1784005233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Additive Manufacturing for Extracellular Vesicle Therapeutics: Engineering Strategies for Production, Isolation, and Delivery"],"prefix":"10.1002","volume":"15","author":[{"given":"Renz Gabriel","family":"Garduque","sequence":"first","affiliation":[{"name":"The Vijay Lab Division of Engineering New York University  Abu Dhabi UAE"},{"name":"Department of Biomedical Engineering Tandon School of Engineering New York University  Brooklyn New York 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