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By exploiting the spontaneous formation of the biomolecular corona (BC) around nanoparticles (NPs), it's possible to capture a rich, disease\u2010specific fingerprint from the plasma that reflects systemic alterations often invisible to traditional diagnostic assays. In the present study, we demonstrate the efficacy of an innovative nanotechnological platform utilizing a synergistic dual\u2010silica NPs system (comprising amino\u2010 and sulfonate\u2010functionalized surfaces) integrated with proteomic and lipidomic profiling of the NP\u2010associated BC. Our results revealed a significant enrichment of ribosomal machinery in the BC of AD patients, contrasted by a simultaneous decrease of glycolytic enzymes and mitochondrial respiratory components. This metabolic impairment is further corroborated by the lipidomic profile, which shows a reduction in short\u2010chain acyl\u2010carnitines (C2, C3, C5) and essential membrane phospholipids. 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