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Existing zinc\u2011based (e.g., zinc oxide (ZnO), and zinc peroxide) nanoparticles often lack internal voids and sufficient surface area, restricting drug loading and functionalization. In this study, we developed a crystallinity\u2011gradient selective etching method to tailor biodegradable hollow mesoporous zinc nanoparticle (HMZN). Typically, zinc peroxide nanoparticles with low\u2011crystallinity core and high\u2011crystallinity shell were synthesized, and ammonia water was used to selectively etch the inner low\u2011crystallinity core, producing HMZN. Hemin (HEM) and Gd\u2011poly(acrylic acid) macrochelates (GP) were then loaded to construct HEM@HMZN@GP for dual\u2010source H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    surge\u2010driven tumor ferroptosis therapy. In acidic tumor microenvironment, Zn\n                    <jats:sup>2+<\/jats:sup>\n                    , H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , HEM, and GP can be released from HEM@HMZN@GP. The released Zn\n                    <jats:sup>2+<\/jats:sup>\n                    damages mitochondrial electron transport chain (ETC) and generates superoxide anions (\u2022O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ), which can be rapidly catalyzed by superoxide dismutase into H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . The dual\u2010source of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    markedly elevates local oxidative stress. HEM can be enzymatically converted by heme oxygenase\u20111 to Fe\n                    <jats:sup>2+<\/jats:sup>\n                    , which reacts with the abundant H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    via Fenton reaction to produce hydroxyl radicals, initiating lipid peroxidation and ferroptosis. GP enhances\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    \u2011weighted magnetic resonance imaging signals, facilitating drug delivery visualization in tumors.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71443","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:45:55Z","timestamp":1784263555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Crystallinity\u2010Gradient Etched Hollow Mesoporous Zinc Nanoparticle for Dual\u2010Source H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    \u2010Driven Tumor Ferroptosis Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Haobin","family":"Cai","sequence":"first","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University Baiyun  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University Baiyun  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehui","family":"Wang","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University Baiyun  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University Baiyun  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingdeng","family":"Fan","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University Baiyun  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Huang","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University Baiyun  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanchao","family":"Que","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University Baiyun  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolong","family":"Ma","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University Baiyun  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshui","family":"Bai","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University Baiyun  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Ren","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University Baiyun  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Yun","sequence":"additional","affiliation":[{"name":"Research Center of Nanomedicine Technology The Second Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Medical Instruments, School of Biomedical Engineering Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shipeng","family":"Ning","sequence":"additional","affiliation":[{"name":"Research Center of Nanomedicine Technology The Second Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0350-375X","authenticated-orcid":false,"given":"Zheyu","family":"Shen","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University Baiyun  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008176\u20104"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","unstructured":"R.JinandT. 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