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The highly oxidative microenvironment and fibrosis of the endometrial wound are critical factors driving IUA pathogenesis. Here, a pH and reactive oxygen species (ROS) dual\u2010responsive hydrogel (DRH) with antifouling property, which could be gelated in situ click chemistry, was developed to effectively treat IUA via anti\u2010oxidative and anti\u2010fibrosis. This DRH was prepared by a dual\u2010crosslinking structure, which was based on the thiol\u2010ene click chemistry reaction of poly(ethylene glycol) diacrylate (PEGDA), 4\u2010arm poly(ethylene glycol) acrylate (4\u2010arm\u2010PEG\u2010AC) and dithiothreitol (DTT), coupled with borate ester bonds between borax and DTT. This DRH presented excellent antifouling and good ROS scavenging, which reduced protein and cell adhesion, as well as alleviated oxidative stress. Additionally, the DRH also exhibited pH and ROS responsiveness, enabling degradation in the intrauterine microenvironment. In the rat endometrial injury model, the DRH successfully exerted an effective therapeutic effect on IUA, and thus eventually restored fertility by attenuating the endometrial oxidative damage, inhibiting the activation of myofibroblasts, and reducing epithelial\u2010mesenchymal transition.<\/jats:p>","DOI":"10.1002\/adhm.71444","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T21:51:36Z","timestamp":1785102696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Situ Click Chemistry Forming pH\/ROS\u2010Responsive and Antifouling Hydrogel to Prevent Intrauterine Adhesion and Restore Fertility"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiepei","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Gynecology Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Zhejiang Chinese Medical University Zhejiang Chinese Medical University  Wenzhou Zhejiang P. 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