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Sonodynamic therapy (SDT) offers a noninvasive strategy for deep\u2010tissue tumor ablation; however, its efficacy is often limited by rapid electron\u2013hole recombination in conventional sonosensitizers, resulting in insufficient reactive oxygen species (ROS). In this study, a biomimetic nanosonosensitizer is rationally engineered via synergistic type II heterojunction interface construction and Cu\u2500N coordination electronic activation. By anchoring Cu\u2500N coordinated carbon dots (Cu\u2010CDs) onto two\u2010dimensional (2D) nanosheets, the compact heterojunction enables spatial charge separation, while Cu\u2500N motifs act as kinetic promoters to accelerate interfacial electron transfer. This co\u2010engineering strategy markedly enhances ultrasound (US) \u2010triggered multi\u2010ROS generation, leading to amplified oxidative stress. Biologically, intracellular copper overload triggers cuproptosis via lipoylated protein aggregation, whereas ROS burst induces PANoptosis\u2010like cell death. Importantly, the synergistic death programs promote robust immunogenic cell death (ICD) with elevated Damage\u2010associated molecular patterns (DAMPs) release\/exposur, thereby activating antitumor immunity and contributing to enhanced therapeutic efficacy against GBM. This work provides new insights into the rational design of highly efficient sonosensitizers and offers new dimensions for precision SDT\u2010based glioma sono\u2010immunotherapy.<\/jats:p>","DOI":"10.1002\/adhm.71451","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:06:01Z","timestamp":1784628361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Heterojunction\/Cu\u2500N Coordination Engineering Drives Cuproptosis and PANoptosis for Sonodynamic Glioblastoma Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Ming","family":"Cheng","sequence":"first","affiliation":[{"name":"Suzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Nanjing University of Chinese Medicine  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and 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