{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:01:03Z","timestamp":1787320863500,"version":"build-2736575974"},"reference-count":70,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Although moderate exercise benefits health, excessive amounts of prolonged, high\u2010intensity exercise may damage tissues and cause inflammation\u2010related diseases. There is a growing interest in exercise\u2010related health monitoring and tracking; however, a handy, noninvasive, and accurate method for wearable detection of exercise\u2010induced inflammation still lacks. Here, this work reports a wireless and passive immunosensor for the noninvasive, low\u2010cost, and simple monitoring of C\u2010reactive protein (CRP) in sweat as an inflammatory marker to evaluate exercise\u2010induced inflammation. The sensor has a sandwich structure, in which the middle layer is an immuno\u2010sensitive hydrogel whose internal network structure cracks with the entry of CRP. A pair of coils converts the change of hydrogel into a shift of radio frequency (RF). The limit of detection (LoD) is as low as pg mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    , covering the concentration range of human sweat CRP. The sensor can be used in direct detection for sweat samples from subjects, demonstrating a correlation between exercise\u2010induced inflammation and exercise intensity. By tracking daily sweat CRP, the wearable passive immunosensor provides a methodology to quantify exercise intensity in terms of inflammation and has potential in customizing personal exercise protocols.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71454","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:26:56Z","timestamp":1784874416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Passive, Electromagnetic\u2010Responsive Hydrogel Immunosensor for Exercise Intensity Monitoring Based on Sweat C\u2010Reactive Protein"],"prefix":"10.1002","volume":"15","author":[{"given":"Hao","family":"Wen","sequence":"first","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering &amp; Instrument Science Zhejiang University  Hangzhou P. R. China"},{"name":"Taizhou Key Laboratory of Medical Devices and Advanced Materials Zhejiang Key Laboratory of Intelligent Medical Decision Support Taizhou Institute of Zhejiang University  Taizhou P. R. China"},{"name":"Innovation Center For Smart Medical Technologies &amp; Devices Binjiang Institute of Zhejiang University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9613-9273","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering &amp; Instrument Science Zhejiang University  Hangzhou P. R. China"},{"name":"Taizhou Key Laboratory of Medical Devices and Advanced Materials Zhejiang Key Laboratory of Intelligent Medical Decision Support Taizhou Institute of Zhejiang University  Taizhou P. R. China"},{"name":"Innovation Center For Smart Medical Technologies &amp; Devices Binjiang Institute of Zhejiang University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyang","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering &amp; Instrument Science Zhejiang University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Computer Science Jiangxi University of Chinese Medicine  Nanchang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujing","family":"Sun","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering &amp; Instrument Science Zhejiang University  Hangzhou P. R. China"},{"name":"Taizhou Key Laboratory of Medical Devices and Advanced Materials Zhejiang Key Laboratory of Intelligent Medical Decision Support Taizhou Institute of Zhejiang University  Taizhou P. R. China"},{"name":"Innovation Center For Smart Medical Technologies &amp; Devices Binjiang Institute of Zhejiang University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqing","family":"Gao","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering &amp; Instrument Science Zhejiang University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Jin","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering &amp; Instrument Science Zhejiang University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghan","family":"Shi","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering &amp; Instrument Science Zhejiang University  Hangzhou P. R. China"},{"name":"Taizhou Key Laboratory of Medical Devices and Advanced Materials Zhejiang Key Laboratory of Intelligent Medical Decision Support Taizhou Institute of Zhejiang University  Taizhou P. R. China"},{"name":"Innovation Center For Smart Medical Technologies &amp; Devices Binjiang Institute of Zhejiang University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaobo","family":"Dai","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering &amp; Instrument Science Zhejiang University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Peng","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering &amp; Instrument Science Zhejiang University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1583-0798","authenticated-orcid":false,"given":"Zijian","family":"An","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering &amp; Instrument Science Zhejiang University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ye","sequence":"additional","affiliation":[{"name":"College of Computer Science Jiangxi University of Chinese Medicine  Nanchang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0115-2279","authenticated-orcid":false,"given":"Bin","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Soil Pollution Control and Safety Zhejiang Key Laboratory of Excited\u2010State Energy Conversion and Energy Storage Institute of Analytical Chemistry Department of Chemistry Zhejiang University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering &amp; Instrument Science Zhejiang University  Hangzhou P. R. China"},{"name":"Taizhou Key Laboratory of Medical Devices and Advanced Materials Zhejiang Key Laboratory of Intelligent Medical Decision Support Taizhou Institute of Zhejiang University  Taizhou P. R. China"},{"name":"Innovation Center For Smart Medical Technologies &amp; Devices Binjiang Institute of Zhejiang University  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201004183\u2010x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40359\u2010024\u201001558\u20103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adi5377"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abi7282"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2024.116187"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16213663"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi5200"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010023\u201000921\u20109"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.06.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2026.116420"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010025\u201002308\u20107"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40798\u2010025\u201000857\u20102"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.12965\/jer.2550152.076"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17020199"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo15060405"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15030314"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0022\u20104707.24.16206\u20108"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.29219\/fnr.v69.11036"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1720431"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0779"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595\u2010024\u201002813\u20101"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0652"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16521"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq5916"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0835"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c04456"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202005958"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010023\u201001059\u20105"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biosx.2023.100435"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaa191"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0571"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj0268"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201048294\u20101"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201904549"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201051279\u20109"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103079"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202408022"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1109\/Jsen.2024.3360856"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274\u2010024\u20106738\u20107"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1109\/Jsen.2022.3174210"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007383\u20103"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201047851\u2010y"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adj4397"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202504959"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202205326"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820\u2010022\u201000819\u20103"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42114\u2010023\u201000749\u20107"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c08830"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c06164"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.143173"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022109\u2010z"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1109\/Tap.2017.2671036"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.168154"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5ma00019j"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/cta.4055"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746\u2010024\u201001404\u20101"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2018.12.150"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2018.02.075"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.05.035"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2018.06.017"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c03812"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2016.09.020"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201500315"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mee.2019.110993"},{"key":"e_1_2_10_66_1","unstructured":"E. A.Al\u2010Enezi Developing an Europium\u2010based Optical Biosensor for Detection of Protein Biomarkers(2020)."},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2021.111544"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0040497"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202405896"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.140609"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.5c03500"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71454","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71454","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:00:24Z","timestamp":1787317224000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":70,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/adhm.71454"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71454","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"assertion":[{"value":"2026-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71454"}}