{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:00:00Z","timestamp":1787320800735,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22478060"],"award-info":[{"award-number":["22478060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22208046"],"award-info":[{"award-number":["22208046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22408042"],"award-info":[{"award-number":["22408042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Photothermal therapy (PTT) has emerged as a promising strategy for tumor treatment, owing to its exceptional treatment outcomes and spatiotemporal control. However, persistent challenges, such as high\u2010energy laser\u2010induced damage to surrounding tissue and induces a cascade of heat shock responses (HSRs) in tumor cells, collectively contribute to suboptimal therapeutic outcomes. In addition, single\u2010modality treatment approaches often fail to attain optimal therapeutic efficacy. In this study, we designed a gas\/PTT nanocomposite material (PTZSCN\u2010NO NPs) that integrates the photothermal molecule phenothiazin\u2010thiophen\u2010dimethylfuran (PTZSCN) with a thermosensitive nitric oxide (NO) donor (S\u2010nitroso\u2010N\u2010acetylpenicillamine, SNAP). Upon laser irradiation, PTZSCN generates heat for PTT and promotes the release of NO from SNAP, can inhibit the expression of multiple HSPs, thus enhancing the efficacy of PTT. Furthermore, upon light exposure, PTZSCN\u2010NO NPs generate a photothermal effect, leading to mitochondrial damage, caspase\u20101 activation, and gasdermin D cleavage. These events ultimately induce pyroptosis, achieving a synergistic gas\/photothermal therapeutic effect and suppressed orthotopic breast tumor growth and metastasis in a tumor\u2010bearing mice model. This approach optimizes conventional PTT and providing a repeatable, noninvasive treatment process.<\/jats:p>","DOI":"10.1002\/adhm.71458","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T03:33:42Z","timestamp":1784518422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Gas Phototheranostic Nanocomposite Integrates Photothermal Molecule With Thermal\u2010Sensitive Nitric Oxide Donor for Anticancer Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Qiushi","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maomao","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyang","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Pan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Dalian University of Technology  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4962-5186","authenticated-orcid":false,"given":"Jiangli","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"},{"name":"Ningbo Institute of Dalian University of Technology  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4316-5350","authenticated-orcid":false,"given":"Wen","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"},{"name":"Ningbo Institute of Dalian University of Technology  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8806-322X","authenticated-orcid":false,"given":"Xiaojun","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202311365"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202304421"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202101009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202002516"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201900501"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202008481"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202504769"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010020\u201000749\u20105"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.4c03574"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c07558"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.3.1.625"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202311622"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b04954"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00018"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121017"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201800594"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202404265"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029121\u2010x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c03348"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901954"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201704490"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs15273h"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301901"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0nr07484e"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01672"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8tb02552e"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c10053"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202409966"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202508713"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201901223"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5cs00083a"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5cc00219b"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202310706"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201055083\u20103"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202507157"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202407115"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202410336"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202516383"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202523608"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71458","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71458","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:00:17Z","timestamp":1787317217000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,19]]},"references-count":41,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/adhm.71458"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71458","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,19]]},"assertion":[{"value":"2025-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71458"}}