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In this study, we explore the potential of MoS\n                    <jats:sub>2<\/jats:sub>\n                    nanodots engineered with sulfur vacancies, small sizes, hydrophilicity and surface positive charge as eye drops for effective fungal keratitis management. The tailored MoS\n                    <jats:sub>2<\/jats:sub>\n                    nanodot\u2010based hybrid nanomaterials (HNAF) exhibit remarkable antifungal efficacy through a synergistic interaction of their abundant sulfur vacancies and positive surface charges. The ultrasmall size and positive surface charge of HNAF allow the nanodots to pass through corneal epithelial barriers and electrostatically bind to the negatively charged cell membranes of\n                    <jats:italic>Fusarium solani<\/jats:italic>\n                    . The rich sulfur vacancies act as active catalytic centers that decompose local H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    into toxic hydroxyl radicals (\u2022OH) and deplete intracellular GSH under dark physiological conditions, without requiring external stimuli in fungal cells. This cooperation between barrier penetration and targeted catalytic oxidation leads to significant antifungal activity in vitro and in vivo with excellent biosafety. This research underscores the potential of MoS\n                    <jats:sub>2<\/jats:sub>\n                    nanodot\u2010based hybrid nanomaterials as a step forward in managing fungal keratitis, offering an antibiotic\u2010free, safe, and potent alternative to current therapeutic modalities.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71459","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:29:47Z","timestamp":1785472187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sulfur Vacancy\u2010Rich MoS\n                    <sub>2<\/sub>\n                    Nanodot\u2010Based Hybrid Eye Drops as an Antibiotic\u2010Free Antifungus for Fungal Keratitis Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Ruixing","family":"Liu","sequence":"first","affiliation":[{"name":"Henan Eye Hospital, Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwen","family":"Geng","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital, Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Chen","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital, Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital, Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou 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