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Here, we developed an injectable catechol\u2010functionalized carboxymethyl cellulose hydrogel, CMCDA, as a bioadhesive and antioxidative intravitreal platform. Through dopamine grafting and oxidative crosslinking, CMCDA exhibited shear\u2010thinning injectability, self\u2010healing behavior, wet\u2010tissue adhesion, controlled biodegradability, and good biocompatibility. In an optic nerve crush model, CMCDA significantly reduced retinal reactive oxygen species (ROS) accumulation, preserved retinal ganglion cells, promoted axonal regeneration, and attenuated microglial activation, with 7 wt% CMCDA showing the strongest therapeutic efficacy. Single\u2010cell RNA sequencing further suggested that CMCDA reshaped the injured retinal microenvironment by suppressing apoptotic, oxidative\u2010stress, and inflammatory pathways while supporting phototransduction\u2010related programs. Importantly, these structural and molecular benefits were accompanied by improved visual function, as confirmed by visual cliff testing and electroretinography. Overall, CMCDA represents a multifunctional cellulose\u2010based hydrogel platform for minimally invasive antioxidative neuroprotection, axonal repair, and functional recovery after optic nerve injury.<\/jats:p>","DOI":"10.1002\/adhm.71461","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:04:42Z","timestamp":1784621082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifunctional Catechol\u2010Functionalized Cellulose Hydrogels for the Minimally Invasive Treatment of Acute Optic Nerve Injuries"],"prefix":"10.1002","volume":"15","author":[{"given":"Kai\u2010Hsiang","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Ke","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology 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