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However, most of them consist of single\u2010component that induces dissatisfactory therapeutic effects, imposing obstacles to their widespread applications. Herein, a carrier\u2010free herbal hydrogel fabricated by co\u2010assembly of medicative mangiferin and polydatin is invented for treating MRSA\u2010infected diabetic wound, where \u03c0\u2013\u03c0 stacking and hydrogen bonding guide the formation of the hydrogel. The as\u2010prepared hydrogel is suitable for use as a wound dressing due to its high thermostability, continuous release, biodegradability, and outstanding mechanical properties. Remarkable bacterial suppression and massive bacterial biofilm removal are discerned after applying the co\u2010assembled hydrogel. It also exhibits the capacity to recruit healing\u2010related cells, scavenge ROS, and expedite revascularization. The dysfunction of macrophages is ameliorated, tending to transform to an anti\u2010inflammatory M2 phenotype rather than proinflammatory M1 phenotype. It is these therapeutic efficacies that ascertain high\u2010performance wound restoration in diabetic rats, where bacteria are eradicated, inflammatory are alleviated, re\u2010epithelialization, revascularization, and collagen deposition are accelerated. Notably, the current study not only furnishes a hydrogel wound dressing for healing MRSA\u2010infected diabetic wound, but also opens up new prospects for reformation of herbal\u2010based carrier\u2010free hydrogel.<\/jats:p>","DOI":"10.1002\/adhm.71468","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:35:31Z","timestamp":1784781331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Binary Natural Herbal Co\u2010Assembled Hydrogel for Expediting MRSA\u2010Infected Diabetic Wound Healing via Robust Sterilization, Anti\u2010Inflammation and Tissue Repair"],"prefix":"10.1002","volume":"15","author":[{"given":"Yuhui","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Research &amp; Development of Characteristic Qin Medicine Resources (Cultivation) Co\u2010Construction Collaborative Innovation Center for Chinese Medicine Resources 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