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Here, we present a proof\u2010of\u2010concept guidewire\u2010based biopsy system that integrates magnetic actuation for flexible navigation with fluorescence imaging for targeted lesion identification. The system comprises a magnetically driven biopsy tool, a miniaturized camera with an optical filter, a 488\u00a0nm laser fiber for fluorescence excitation, and a white\u2010light illumination fiber. Under external magnetic field control (10\u201340 mT), the system achieved a maximum deflection angle of 32.60\u00b0 \u00b1 1.03\u00b0 (90\u00b0 magnetic field) and successfully navigated through a scaled bronchial phantom to reach multiple target branches. Using FITC\u2010conjugated anti\u2010EGFR antibody\u2010labeled A549 cell spheroids as simulated tumor targets, the system demonstrated real\u2010time fluorescence identification and targeted biopsy, recovering 23.40% \u00b1 2.63% of spheroid cells per sampling session. Navigation and biopsy capabilities were further validated in ex vivo porcine lungs. This integrated approach addresses both the navigation and target identification challenges inherent in peripheral lung biopsy and provides a foundation for future development toward clinical application.<\/jats:p>","DOI":"10.1002\/adhm.71473","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:06:12Z","timestamp":1784700372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a Novel Fluorescent Recognition Guidewire System Toward Early Lung Cancer Biopsy"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiatian","family":"Chen","sequence":"first","affiliation":[{"name":"School of Medical Science and Engineering Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medical Science and Engineering Beijing Institute of 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